Seroatlas · Human Serome Atlas

GPR88

G protein-coupled receptor 88

Also known as: GPR88_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9GZN0
Gene
GPR88
Ensembl
ENSG00000181656
Chromosome
1
Canonical length
384 aa
Protein class
Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a G protein-coupled receptor found almost exclusively in the striatum, a brain structure that controls motor function and cognition. Defects in this gene have been associated with chorea, speech delay, and learning difficulties, as well as some neuropsychiatric disorders. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

384 residues, UniProt reviewed canonical sequence.

>Q9GZN0|GPR88
     1  MTNSSSTSTS STTGGSLLLL CEEEESWAGR RIPVSLLYSG LAIGGTLANG MVIYLVSSFR
    61  KLQTTSNAFI VNGCAADLSV CALWMPQEAV LGLLPTGSAE PPADWDGAGG SYRLLRGGLL
   121  GLGLTVSLLS HCLVALNRYL LITRAPATYQ ALYQRRHTAG MLALSWALAL GLVLLLPPWA
   181  PRPGAAPPRV HYPALLAAAA LLAQTALLLH CYLGIVRRVR VSVKRVSVLN FHLLHQLPGC
   241  AAAAAAFPGA QHAPGPGGAA HPAQAQPLPP ALHPRRAQRR LSGLSVLLLC CVFLLATQPL
   301  VWVSLASGFS LPVPWGVQAA SWLLCCALSA LNPLLYTWRN EEFRRSVRSV LPGVGDAAAA
   361  AVAATAVPAV SQAQLGTRAA GQHW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR88 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
74 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 74 nTPM
  • spleen: 9.9 nTPM
  • liver: 8.3 nTPM
  • breast: 6.7 nTPM
  • cerebral cortex: 3 nTPM
  • hypothalamus: 2.4 nTPM

Single-cell type

  • brain inhibitory neurons: 49 nCPM
  • pituicytes/fscs: 32 nCPM
  • retinal amacrine cells: 19 nCPM
  • other brain neurons: 4.2 nCPM
  • platelets: 2.8 nCPM
  • brain excitatory neurons: 2.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 201 nTPM
  • medulla oblongata: 22 nTPM
  • thalamus: 16 nTPM
  • cerebral cortex: 15 nTPM
  • hypothalamus: 14 nTPM
  • amygdala: 6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GPR88.

Disease | AllUniProt

Conditions GPR88 is implicated in, by any mechanism.

  • Chorea, childhood-onset, with psychomotor retardation (COCPMR) MIM:616939

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 103 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Chorea, childhood-onset, with psychomotor retardation

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.53
gnomAD pLI
0.75
gnomAD missense Z
3.03
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR88 as an antibody target. Whether an autoantibody or antibody against GPR88 could matter depends on whether native GPR88 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR88 is annotated at the cell surface, where native GPR88 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR88 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GPR88. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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