Seroatlas · Human Serome Atlas

GPR87

G-protein coupled receptor 87

Also known as: GPR87_HUMAN, GPR95

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BY21
Gene: GPR87
Ensembl: ENSG00000138271
Chromosome: 3
Canonical length: 358 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Lipid droplets,Mitochondria

OverviewNCBI Gene

This gene encodes a G protein-coupled receptor and is located in a cluster of G protein-couple receptor genes on chromosome 3. The encoded protein has been shown to be overexpressed in lung squamous cell carcinoma (PMID:18057535) and regulated by p53 (PMID:19602589). [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

358 residues, UniProt reviewed canonical sequence.

>Q9BY21|GPR87
     1  MGFNLTLAKL PNNELHGQES HNSGNRSDGP GKNTTLHNEF DTIVLPVLYL IIFVASILLN
    61  GLAVWIFFHI RNKTSFIFYL KNIVVADLIM TLTFPFRIVH DAGFGPWYFK FILCRYTSVL
   121  FYANMYTSIV FLGLISIDRY LKVVKPFGDS RMYSITFTKV LSVCVWVIMA VLSLPNIILT
   181  NGQPTEDNIH DCSKLKSPLG VKWHTAVTYV NSCLFVAVLV ILIGCYIAIS RYIHKSSRQF
   241  ISQSSRKRKH NQSIRVVVAV FFTCFLPYHL CRIPFTFSHL DRLLDESAQK ILYYCKEITL
   301  FLSACNVCLD PIIYFFMCRS FSRRLFKKSN IRTRSESIRS LQSVRRSEVR IYYDYTDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR87 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

esophagus: 42 nTPM
skin: 37 nTPM
vagina: 28 nTPM
cervix: 20 nTPM
salivary gland: 15 nTPM
urinary bladder: 12 nTPM

Single-cell type

epididymal basal cells: 379 nCPM
syncytiotrophoblasts: 316 nCPM
esophageal apical cells: 296 nCPM
esophageal suprabasal cells: 139 nCPM
urothelial cells: 127 nCPM
migrating cytotrophoblasts: 100 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 8.3 nTPM
cerebral cortex: 3.6 nTPM
white matter: 2.9 nTPM
basal ganglia: 2.2 nTPM
cerebellum: 2.1 nTPM
thalamus: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: -0.26
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR87 as an antibody target. Whether an autoantibody or antibody against GPR87 could matter depends on whether native GPR87 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR87 is annotated at the cell surface, where native GPR87 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR87 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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