Seroatlas · Human Serome Atlas

GPR82

Probable G-protein coupled receptor 82

Also known as: GPR82_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96P67
Gene: GPR82
Ensembl: ENSG00000171657
Chromosome: X
Canonical length: 336 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is an orphan G protein-coupled receptor of unknown function. The encoded protein is a member of a family of proteins that contain seven transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

336 residues, UniProt reviewed canonical sequence.

>Q96P67|GPR82
     1  MNNNTTCIQP SMISSMALPI IYILLCIVGV FGNTLSQWIF LTKIGKKTST HIYLSHLVTA
    61  NLLVCSAMPF MSIYFLKGFQ WEYQSAQCRV VNFLGTLSMH ASMFVSLLIL SWIAISRYAT
   121  LMQKDSSQET TSCYEKIFYG HLLKKFRQPN FARKLCIYIW GVVLGIIIPV TVYYSVIEAT
   181  EGEESLCYNR QMELGAMISQ IAGLIGTTFI GFSFLVVLTS YYSFVSHLRK IRTCTSIMEK
   241  DLTYSSVKRH LLVIQILLIV CFLPYSIFKP IFYVLHQRDN CQQLNYLIET KNILTCLASA
   301  RSSTDPIIFL LLDKTFKKTL YNLFTKSNSA HMQSYG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR82 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 6.5 nTPM

Expression across tissuesHPA

Tissue

tonsil: 6.5 nTPM
lymph node: 3 nTPM
small intestine: 2.5 nTPM
appendix: 2.2 nTPM
duodenum: 1.6 nTPM
rectum: 1.1 nTPM

Single-cell type

kupffer cells: 64 nCPM
epicardial cells: 30 nCPM
innate lymphoid cells: 23 nCPM
macrophages: 20 nCPM
retinal ganglion cells: 19 nCPM
t-cells: 15 nCPM

Immune cell

eosinophil: 40 nTPM
NK-cell: 11 nTPM
intermediate monocyte: 2.5 nTPM
non-classical monocyte: 2.4 nTPM
classical monocyte: 0.4 nTPM
myeloid DC: 0.3 nTPM

Brain region

medulla oblongata: 4.4 nTPM
hypothalamus: 4.2 nTPM
white matter: 3.3 nTPM
cerebellum: 3.1 nTPM
midbrain: 3.1 nTPM
pons: 3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0.14
gnomAD missense Z: 0.56
DepMap mean gene effect: 0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

G protein-coupled receptor activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
7 transmembrane receptor (rhodopsin family)
Probable G-protein coupled receptor 82

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR82 as an antibody target. Whether an autoantibody or antibody against GPR82 could matter depends on whether native GPR82 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR82 is annotated at the cell surface, where native GPR82 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR82 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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