Seroatlas · Human Serome Atlas

GPR75

Probable G-protein coupled receptor 75

Also known as: GPR75_HUMAN, WI-31133

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95800
Gene: GPR75
Ensembl: ENSG00000119737
Chromosome: 2
Canonical length: 540 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand.[supplied by OMIM, Jul 2002]

Canonical amino-acid sequenceUniProt

540 residues, UniProt reviewed canonical sequence.

>O95800|GPR75
     1  MNSTGHLQDA PNATSLHVPH SQEGNSTSLQ EGLQDLIHTA TLVTCTFLLA VIFCLGSYGN
    61  FIVFLSFFDP AFRKFRTNFD FMILNLSFCD LFICGVTAPM FTFVLFFSSA SSIPDAFCFT
   121  FHLTSSGFII MSLKTVAVIA LHRLRMVLGK QPNRTASFPC TVLLTLLLWA TSFTLATLAT
   181  LKTSKSHLCL PMSSLIAGKG KAILSLYVVD FTFCVAVVSV SYIMIAQTLR KNAQVRKCPP
   241  VITVDASRPQ PFMGVPVQGG GDPIQCAMPA LYRNQNYNKL QHVQTRGYTK SPNQLVTPAA
   301  SRLQLVSAIN LSTAKDSKAV VTCVIIVLSV LVCCLPLGIS LVQVVLSSNG SFILYQFELF
   361  GFTLIFFKSG LNPFIYSRNS AGLRRKVLWC LQYIGLGFFC CKQKTRLRAM GKGNLEVNRN
   421  KSSHHETNSA YMLSPKPQKK FVDQACGPSH SKESMVSPKI SAGHQHCGQS SSTPINTRIE
   481  PYYSIYNSSP SQEESSPCNL QPVNSFGFAN SYIAMHYHTT NDLVQEYDST SAKQIPVPSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR75 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 9.8 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 9.8 nTPM
retina: 7.1 nTPM
basal ganglia: 5 nTPM
amygdala: 3.9 nTPM
parathyroid gland: 3.1 nTPM
midbrain: 2.7 nTPM

Single-cell type

corticotrophs: 0.1 nCPM
ependymal cells: 0.1 nCPM
epididymal efferent duct absorptive cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

neutrophil: 0.2 nTPM
memory B-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM

Brain region

midbrain: 74 nTPM
thalamus: 73 nTPM
hypothalamus: 59 nTPM
amygdala: 58 nTPM
medulla oblongata: 58 nTPM
basal ganglia: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
gnomAD missense Z: -0.04
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR75 as an antibody target. Whether an autoantibody or antibody against GPR75 could matter depends on whether native GPR75 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR75 is annotated at the cell surface, where native GPR75 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR75 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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