Seroatlas · Human Serome Atlas

GPR68

G-protein coupled receptor 68

Also known as: GPR68_HUMAN, OGR1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15743
Gene
GPR68
Ensembl
ENSG00000119714
Chromosome
14
Canonical length
365 aa
Protein class
Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a G protein-coupled receptor for sphingosylphosphorylcholine. The encoded protein is a proton-sensing receptor, inactive at pH 7.8 but active at pH 6.8. Mutations in this gene are a cause of amelogenesis imperfecta. [provided by RefSeq, Feb 2017]

Canonical amino-acid sequenceUniProt

365 residues, UniProt reviewed canonical sequence.

>Q15743|GPR68
     1  MGNITADNSS MSCTIDHTIH QTLAPVVYVT VLVVGFPANC LSLYFGYLQI KARNELGVYL
    61  CNLTVADLFY ICSLPFWLQY VLQHDNWSHG DLSCQVCGIL LYENIYISVG FLCCISVDRY
   121  LAVAHPFRFH QFRTLKAAVG VSVVIWAKEL LTSIYFLMHE EVIEDENQHR VCFEHYPIQA
   181  WQRAINYYRF LVGFLFPICL LLASYQGILR AVRRSHGTQK SRKDQIQRLV LSTVVIFLAC
   241  FLPYHVLLLV RSVWEASCDF AKGVFNAYHF SLLLTSFNCV ADPVLYCFVS ETTHRDLARL
   301  RGACLAFLTC SRTGRAREAY PLGAPEASGK SGAQGEEPEL LTKLHPAFQT PNSPGSGGFP
   361  TGRLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR68 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 12 nTPM
  • esophagus: 8.5 nTPM
  • urinary bladder: 7 nTPM
  • skin: 5.9 nTPM
  • lymph node: 5.6 nTPM
  • stomach: 5.5 nTPM

Single-cell type

  • innate lymphoid cells: 60 nCPM
  • hofbauer cells: 47 nCPM
  • epicardial cells: 36 nCPM
  • cardiomyocytes: 29 nCPM
  • t-cells: 28 nCPM
  • somatotrophs: 28 nCPM

Immune cell

  • gdT-cell: 23 nTPM
  • NK-cell: 20 nTPM
  • MAIT T-cell: 14 nTPM
  • memory CD8 T-cell: 14 nTPM
  • T-reg: 8.8 nTPM
  • memory CD4 T-cell: 5 nTPM

Brain region

  • cerebral cortex: 14 nTPM
  • pons: 12 nTPM
  • cerebellum: 11 nTPM
  • hypothalamus: 11 nTPM
  • midbrain: 9.4 nTPM
  • thalamus: 9.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GPR68.

Disease | AllUniProt

Conditions GPR68 is implicated in, by any mechanism.

  • Amelogenesis imperfecta, hypomaturation type, 2A6 (AI2A6) MIM:617217

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 81 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.36
gnomAD pLI
0
gnomAD missense Z
1.19
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR68 as an antibody target. Whether an autoantibody or antibody against GPR68 could matter depends on whether native GPR68 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR68 is annotated at the cell surface, where native GPR68 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR68 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GPR68. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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