Seroatlas · Human Serome Atlas

GPR63

Probable G-protein coupled receptor 63

Also known as: GPR63_HUMAN, PSP24(beta), PSP24B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZJ6
Gene: GPR63
Ensembl: ENSG00000112218
Chromosome: 6
Canonical length: 419 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in cytosol; nucleoplasm; and plasma membrane. Part of receptor complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

419 residues, UniProt reviewed canonical sequence.

>Q9BZJ6|GPR63
     1  MVFSAVLTAF HTGTSNTTFV VYENTYMNIT LPPPFQHPDL SPLLRYSFET MAPTGLSSLT
    61  VNSTAVPTTP AAFKSLNLPL QITLSAIMIF ILFVSFLGNL VVCLMVYQKA AMRSAINILL
   121  ASLAFADMLL AVLNMPFALV TILTTRWIFG KFFCRVSAMF FWLFVIEGVA ILLIISIDRF
   181  LIIVQRQDKL NPYRAKVLIA VSWATSFCVA FPLAVGNPDL QIPSRAPQCV FGYTTNPGYQ
   241  AYVILISLIS FFIPFLVILY SFMGILNTLR HNALRIHSYP EGICLSQASK LGLMSLQRPF
   301  QMSIDMGFKT RAFTTILILF AVFIVCWAPF TTYSLVATFS KHFYYQHNFF EISTWLLWLC
   361  YLKSALNPLI YYWRIKKFHD ACLDMMPKSF KFLPQLPGHT KRRIRPSAVY VCGEHRTVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR63 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 2.5 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 2.5 nTPM
testis: 2.3 nTPM
choroid plexus: 2 nTPM
cerebral cortex: 1.6 nTPM
rectum: 1.6 nTPM
basal ganglia: 1.4 nTPM

Single-cell type

choroid plexus epithelial cells: 113 nCPM
granulosa cells: 67 nCPM
late spermatids: 56 nCPM
late primary spermatocytes: 53 nCPM
brain inhibitory neurons: 47 nCPM
early primary spermatocytes: 39 nCPM

Immune cell

neutrophil: 0.4 nTPM
NK-cell: 0.2 nTPM
basophil: 0.1 nTPM
gdT-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

cerebral cortex: 13 nTPM
basal ganglia: 12 nTPM
choroid plexus: 12 nTPM
pons: 10 nTPM
white matter: 9.7 nTPM
cerebellum: 7.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0.2
gnomAD missense Z: 0.51
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

G protein-coupled receptor signaling pathway

Molecular functions

G protein-coupled receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR63 as an antibody target. Whether an autoantibody or antibody against GPR63 could matter depends on whether native GPR63 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR63 is annotated at the cell surface, where native GPR63 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR63 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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