Seroatlas · Human Serome Atlas

GPR55

G-protein coupled receptor 55

Also known as: GPR55_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2T6
Gene: GPR55
Ensembl: ENSG00000135898
Chromosome: 2
Canonical length: 319 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

319 residues, UniProt reviewed canonical sequence.

>Q9Y2T6|GPR55
     1  MSQQNTSGDC LFDGVNELMK TLQFAVHIPT FVLGLLLNLL AIHGFSTFLK NRWPDYAATS
    61  IYMINLAVFD LLLVLSLPFK MVLSQVQSPF PSLCTLVECL YFVSMYGSVF TICFISMDRF
   121  LAIRYPLLVS HLRSPRKIFG ICCTIWVLVW TGSIPIYSFH GKVEKYMCFH NMSDDTWSAK
   181  VFFPLEVFGF LLPMGIMGFC CSRSIHILLG RRDHTQDWVQ QKACIYSIAA SLAVFVVSFL
   241  PVHLGFFLQF LVRNSFIVEC RAKQSISFFL QLSMCFSNVN CCLDVFCYYF VIKEFRMNIR
   301  AHRPSRVQLV LQDTTISRG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR55 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 4.4 nTPM

Expression across tissuesHPA

Tissue

testis: 4.4 nTPM
tonsil: 4.2 nTPM
spleen: 3.9 nTPM
basal ganglia: 3.5 nTPM
lymph node: 2.7 nTPM
small intestine: 2.1 nTPM

Single-cell type

sertoli cells: 56 nCPM
tuft cells: 46 nCPM
t-cells: 12 nCPM
plasma cells: 10 nCPM
platelets: 9.9 nCPM
early spermatids: 5.8 nCPM

Immune cell

naive B-cell: 1.9 nTPM
total PBMC: 1.7 nTPM
T-reg: 1.3 nTPM
naive CD8 T-cell: 0.9 nTPM
NK-cell: 0.9 nTPM
plasmacytoid DC: 0.7 nTPM

Brain region

basal ganglia: 9.6 nTPM
hypothalamus: 2.3 nTPM
thalamus: 1.5 nTPM
cerebral cortex: 1.1 nTPM
hippocampal formation: 0.9 nTPM
white matter: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.71
gnomAD pLI: 0
gnomAD missense Z: 0.71
DepMap mean gene effect: 0.16
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR55 as an antibody target. Whether an autoantibody or antibody against GPR55 could matter depends on whether native GPR55 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR55 is annotated at the cell surface, where native GPR55 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR55 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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