Seroatlas · Human Serome Atlas

GPR52

G-protein coupled receptor 52

Also known as: GPR52_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2T5
Gene: GPR52
Ensembl: ENSG00000203737
Chromosome: 1
Canonical length: 361 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Members of the G protein-coupled receptor (GPR) family play important roles in signal transduction from the external environment to the inside of the cell.[supplied by OMIM, Jul 2002]

Canonical amino-acid sequenceUniProt

361 residues, UniProt reviewed canonical sequence.

>Q9Y2T5|GPR52
     1  MNESRWTEWR ILNMSSGIVN VSERHSCPLG FGHYSVVDVC IFETVVIVLL TFLIIAGNLT
    61  VIFVFHCAPL LHHYTTSYFI QTMAYADLFV GVSCLVPTLS LLHYSTGVHE SLTCQVFGYI
   121  ISVLKSVSMA CLACISVDRY LAITKPLSYN QLVTPCRLRI CIILIWIYSC LIFLPSFFGW
   181  GKPGYHGDIF EWCATSWLTS AYFTGFIVCL LYAPAAFVVC FTYFHIFKIC RQHTKEINDR
   241  RARFPSHEVD SSRETGHSPD RRYAMVLFRI TSVFYMLWLP YIIYFLLESS RVLDNPTLSF
   301  LTTWLAISNS FCNCVIYSLS NSVFRLGLRR LSETMCTSCM CVKDQEAQEP KPRKRANSCS
   361  I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR52 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 5.1 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 5.1 nTPM
cerebral cortex: 1.3 nTPM
pituitary gland: 0.6 nTPM
hypothalamus: 0.5 nTPM
bone marrow: 0.4 nTPM
stomach: 0.2 nTPM

Single-cell type

pancreatic acinar cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 32 nTPM
cerebellum: 12 nTPM
choroid plexus: 10 nTPM
cerebral cortex: 8.3 nTPM
hypothalamus: 7.5 nTPM
white matter: 5.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0.01
gnomAD missense Z: 0.78
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR52 as an antibody target. Whether an autoantibody or antibody against GPR52 could matter depends on whether native GPR52 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR52 is annotated at the cell surface, where native GPR52 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR52 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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