Seroatlas · Human Serome Atlas

GPR45

Probable G-protein coupled receptor 45

Also known as: GPR45_HUMAN, PSP24, PSP24A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y5Y3
Gene: GPR45
Ensembl: ENSG00000135973
Chromosome: 2
Canonical length: 372 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

372 residues, UniProt reviewed canonical sequence.

>Q9Y5Y3|GPR45
     1  MACNSTSLEA YTYLLLNTSN ASDSGSTQLP APLRISLAIV MLLMTVVGFL GNTVVCIIVY
    61  QRPAMRSAIN LLLATLAFSD IMLSLCCMPF TAVTLITVRW HFGDHFCRLS ATLYWFFVLE
   121  GVAILLIISV DRFLIIVQRQ DKLNPRRAKV IIAVSWVLSF CIAGPSLTGW TLVEVPARAP
   181  QCVLGYTELP ADRAYVVTLV VAVFFAPFGV MLCAYMCILN TVRKNAVRVH NQSDSLDLRQ
   241  LTRAGLRRLQ RQQQVSVDLS FKTKAFTTIL ILFVGFSLCW LPHSVYSLLS VFSQRFYCGS
   301  SFYATSTCVL WLSYLKSVFN PIVYCWRIKK FREACIELLP QTFQILPKVP ERIRRRIQPS
   361  TVYVCNENQS AV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR45 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 1 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 1 nTPM
hypothalamus: 0.9 nTPM
basal ganglia: 0.7 nTPM
amygdala: 0.5 nTPM
hippocampal formation: 0.5 nTPM
testis: 0.5 nTPM

Single-cell type

late spermatids: 14 nCPM
early spermatids: 6.4 nCPM
late primary spermatocytes: 0.3 nCPM
epididymal basal cells: 0.2 nCPM
retinal bipolar cells: 0.2 nCPM
brain inhibitory neurons: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 7.3 nTPM
midbrain: 5 nTPM
cerebral cortex: 4.8 nTPM
pons: 4.8 nTPM
basal ganglia: 4.4 nTPM
hippocampal formation: 3.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0.1
gnomAD missense Z: 1.29
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR45 as an antibody target. Whether an autoantibody or antibody against GPR45 could matter depends on whether native GPR45 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR45 is annotated at the cell surface, where native GPR45 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR45 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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