Seroatlas · Human Serome Atlas

GPR42

G-protein coupled receptor 42

Also known as: FFAR3L, GPR41L, GPR42_HUMAN, GPR42P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15529
Gene: GPR42
Ensembl: ENSG00000126251
Chromosome: 19
Canonical length: 346 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>O15529|GPR42
     1  MDTGPDQSYF SGNHWFVFSV YLLTFLVGLP LNLLALVVFV GKLRCRPVAV DVLLLNLTAS
    61  DLLLLLFLPF RMVEAANGMH WPLPFILCPL SGFIFFTTIY LTALFLAAVS IERFLSVAHP
   121  LWYKTRPRLG QAGLVSVACW LLASAHCSVV YVIEFSGDIS HSQGTNGTCY LEFRKDQLAI
   181  LLPVRLEMAV VLFVVPLIIT SYCYSRLVWI LGRGGSHRRQ RRVAGLVAAT LLNFLVCFGP
   241  YNVSHVVGYI CGESPVWRIY VTLLSTLNSC VDPFVYYFSS SGFQADFHEL LRRLCGLWGQ
   301  WQQESSMELK EQKGGEEQRA DRPAERKTSE HSQGCGTGGQ VACAEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR42 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 0.6 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0.6 nTPM
colon: 0.4 nTPM
breast: 0.3 nTPM
appendix: 0.2 nTPM
small intestine: 0.2 nTPM
stomach: 0.2 nTPM

Single-cell type

mast cells: 8.6 nCPM
innate lymphoid cells: 4.8 nCPM
monocytes: 3.6 nCPM
neutrophils: 2.5 nCPM
macrophages: 1.8 nCPM
neuroendocrine cells: 1.4 nCPM

Immune cell

eosinophil: 0.4 nTPM
neutrophil: 0.4 nTPM
intermediate monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM

Brain region

medulla oblongata: 0.3 nTPM
choroid plexus: 0.2 nTPM
white matter: 0.2 nTPM
cerebral cortex: 0.1 nTPM
hippocampal formation: 0.1 nTPM
pons: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.66
gnomAD pLI: 0.05
gnomAD missense Z: 1.45

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR42 as an antibody target. Whether an autoantibody or antibody against GPR42 could matter depends on whether native GPR42 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR42 is annotated at the cell surface, where native GPR42 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR42 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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