Seroatlas · Human Serome Atlas

GPR4

G-prodeshotein coupled receptor 4

Also known as: GPR4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P46093
Gene: GPR4
Ensembl: ENSG00000177464
Chromosome: 19
Canonical length: 362 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Enables G protein-coupled receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of Rho protein signal transduction; and response to acidic pH. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

362 residues, UniProt reviewed canonical sequence.

>P46093|GPR4
     1  MGNHTWEGCH VDSRVDHLFP PSLYIFVIGV GLPTNCLALW AAYRQVQQRN ELGVYLMNLS
    61  IADLLYICTL PLWVDYFLHH DNWIHGPGSC KLFGFIFYTN IYISIAFLCC ISVDRYLAVA
   121  HPLRFARLRR VKTAVAVSSV VWATELGANS APLFHDELFR DRYNHTFCFE KFPMEGWVAW
   181  MNLYRVFVGF LFPWALMLLS YRGILRAVRG SVSTERQEKA KIKRLALSLI AIVLVCFAPY
   241  HVLLLSRSAI YLGRPWDCGF EERVFSAYHS SLAFTSLNCV ADPILYCLVN EGARSDVAKA
   301  LHNLLRFLAS DKPQEMANAS LTLETPLTSK RNSTAKAMTG SWAATPPSQG DQVQLKMLPP
   361  AQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 38 nTPM
lung: 27 nTPM
heart muscle: 23 nTPM
breast: 22 nTPM
kidney: 21 nTPM
thyroid gland: 18 nTPM

Single-cell type

pericytes: 0.3 nCPM
lymphatic endothelial cells: 0.2 nCPM
vascular endothelial cells: 0.2 nCPM
vascular smooth muscle cells: 0.2 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM

Immune cell

naive B-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

thalamus: 19 nTPM
pons: 14 nTPM
medulla oblongata: 13 nTPM
midbrain: 13 nTPM
cerebral cortex: 12 nTPM
amygdala: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0.1
gnomAD missense Z: 2.53
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

G protein-coupled receptor activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
7 transmembrane receptor (rhodopsin family)
G protein-coupled receptor 4 orphan

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR4 as an antibody target. Whether an autoantibody or antibody against GPR4 could matter depends on whether native GPR4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR4 is annotated at the cell surface, where native GPR4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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