Seroatlas · Human Serome Atlas

GPR37L1

G-protein coupled receptor 37-like 1

Also known as: ETBR-LP-2, G37L1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60883
Gene: GPR37L1
Ensembl: ENSG00000170075
Chromosome: 1
Canonical length: 481 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins
Subcellular location: Nucleoplasm,Vesicles,Plasma membrane,Cell Junctions

OverviewNCBI Gene

Enables G protein-coupled peptide receptor activity; peptide binding activity; and prosaposin receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and positive regulation of MAPK cascade. Located in plasma membrane. Part of receptor complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

481 residues, UniProt reviewed canonical sequence.

>O60883|GPR37L1
     1  MRWLWPLAVS LAVILAVGLS RVSGGAPLHL GRHRAETQEQ QSRSKRGTED EEAKGVQQYV
    61  PEEWAEYPRP IHPAGLQPTK PLVATSPNPG KDGGTPDSGQ ELRGNLTGAP GQRLQIQNPL
   121  YPVTESSYSA YAIMLLALVV FAVGIVGNLS VMCIVWHSYY LKSAWNSILA SLALWDFLVL
   181  FFCLPIVIFN EITKQRLLGD VSCRAVPFME VSSLGVTTFS LCALGIDRFH VATSTLPKVR
   241  PIERCQSILA KLAVIWVGSM TLAVPELLLW QLAQEPAPTM GTLDSCIMKP SASLPESLYS
   301  LVMTYQNARM WWYFGCYFCL PILFTVTCQL VTWRVRGPPG RKSECRASKH EQCESQLNST
   361  VVGLTVVYAF CTLPENVCNI VVAYLSTELT RQTLDLLGLI NQFSTFFKGA ITPVLLLCIC
   421  RPLGQAFLDC CCCCCCEECG GASEASAANG SDNKLKTEVS SSIYFHKPRE SPPLLPLGTP
   481  C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR37L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 45 nTPM
cerebral cortex: 40 nTPM
amygdala: 39 nTPM
midbrain: 36 nTPM
hippocampal formation: 31 nTPM
hypothalamus: 24 nTPM

Single-cell type

bergmann glia: 210 nCPM
oligodendrocyte progenitor cells: 187 nCPM
astrocytes: 153 nCPM
ependymal cells: 63 nCPM
müller glia: 60 nCPM
oligodendrocytes: 42 nCPM

Immune cell

basophil: 0.4 nTPM
neutrophil: 0.4 nTPM
eosinophil: 0.2 nTPM
naive B-cell: 0.2 nTPM
T-reg: 0.2 nTPM
classical monocyte: 0.1 nTPM

Brain region

thalamus: 271 nTPM
basal ganglia: 267 nTPM
medulla oblongata: 249 nTPM
cerebellum: 248 nTPM
midbrain: 236 nTPM
spinal cord: 218 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
gnomAD missense Z: 0.63
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR37L1 as an antibody target. Whether an autoantibody or antibody against GPR37L1 could matter depends on whether native GPR37L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR37L1 is annotated at the cell surface, where native GPR37L1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR37L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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