Seroatlas · Human Serome Atlas

GPR34

Probable G-protein coupled receptor 34

Also known as: GPR34_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UPC5
Gene: GPR34
Ensembl: ENSG00000171659
Chromosome: X
Canonical length: 381 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM, Apr 2006]

Canonical amino-acid sequenceUniProt

381 residues, UniProt reviewed canonical sequence.

>Q9UPC5|GPR34
     1  MRSHTITMTT TSVSSWPYSS HRMRFITNHS DQPPQNFSAT PNVTTCPMDE KLLSTVLTTS
    61  YSVIFIVGLV GNIIALYVFL GIHRKRNSIQ IYLLNVAIAD LLLIFCLPFR IMYHINQNKW
   121  TLGVILCKVV GTLFYMNMYI SIILLGFISL DRYIKINRSI QQRKAITTKQ SIYVCCIVWM
   181  LALGGFLTMI ILTLKKGGHN STMCFHYRDK HNAKGEAIFN FILVVMFWLI FLLIILSYIK
   241  IGKNLLRISK RRSKFPNSGK YATTARNSFI VLIIFTICFV PYHAFRFIYI SSQLNVSSCY
   301  WKEIVHKTNE IMLVLSSFNS CLDPVMYFLM SSNIRKIMCQ LLFRRFQGEP SRSESTSEFK
   361  PGYSLHDTSV AVKIQSSSKS T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

placenta: 40 nTPM
adipose tissue: 27 nTPM
breast: 20 nTPM
lymph node: 19 nTPM
adrenal gland: 16 nTPM
gallbladder: 16 nTPM

Single-cell type

hofbauer cells: 517 nCPM
microglia: 283 nCPM
kupffer cells: 271 nCPM
macrophages: 186 nCPM
mast cells: 52 nCPM
epicardial cells: 34 nCPM

Immune cell

basophil: 326 nTPM
eosinophil: 113 nTPM
NK-cell: 14 nTPM
intermediate monocyte: 12 nTPM
classical monocyte: 9.4 nTPM
non-classical monocyte: 6.7 nTPM

Brain region

white matter: 41 nTPM
medulla oblongata: 24 nTPM
spinal cord: 21 nTPM
thalamus: 21 nTPM
pons: 17 nTPM
hypothalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0.26
gnomAD missense Z: 1.71
DepMap mean gene effect: 0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

G protein-coupled receptor signaling pathway

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
7 transmembrane receptor (rhodopsin family)
Probable G protein-coupled receptor 34, 7TM

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR34 as an antibody target. Whether an autoantibody or antibody against GPR34 could matter depends on whether native GPR34 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR34 is annotated at the cell surface, where native GPR34 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR34 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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