Seroatlas · Human Serome Atlas

GPR33

Probable G-protein coupled receptor 33

Also known as: GPR33_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q49SQ1
Gene: GPR33
Ensembl: ENSG00000214943
Chromosome: 14
Canonical length: 333 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene has been identified as an orphan chemoattractant G-protein-coupled receptors (GPCR) pseudogene. Studies have shown that the inactivated gene is present as the predominant allele in the human population. A small fraction of the human population has been found to harbor an intact allele.[provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

333 residues, UniProt reviewed canonical sequence.

>Q49SQ1|GPR33
     1  MDLINSTDYL INASTLVRNS TQFLAPASKM IIALSLYISS IIGTITNGLY LWVLRFKMKQ
    61  TVNTLLFFHL ILSYFISTMI LPFMATSQLQ DNHWNFGTAL CKVFNGTLSL GMFTSVFFLS
   121  AIGLDRYLLT LHPVWSQQHR TPRWASSIVL GVWISAAALS IPYLIFRETH HDRKGKVTCQ
   181  NNYAVSTNWE SKEMQASRQW IHVACFISRF LLGFLLPFFI IIFCYERVAS KVKERSLFKS
   241  SKPFKVMMTA IISFFVCWMP YHIHQGLLLT TNQSLLLELT LILTVLTTSF NTIFSPTLYL
   301  FVGENFKKVF KKSILALFES TFSEDSSVER TQT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR33 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

spleen: 0.2 nTPM
appendix: 0.1 nTPM
duodenum: 0.1 nTPM
esophagus: 0.1 nTPM
lymph node: 0.1 nTPM
tonsil: 0.1 nTPM

Single-cell type

cdc: 1 nCPM
b-cells: 0.3 nCPM
somatotrophs: 0.3 nCPM
bergmann glia: 0.2 nCPM
early primary spermatocytes: 0.2 nCPM
macrophages: 0.2 nCPM

Immune cell

myeloid DC: 2.6 nTPM
eosinophil: 0.8 nTPM
classical monocyte: 0.4 nTPM
total PBMC: 0.2 nTPM
basophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR33 as an antibody target. Whether an autoantibody or antibody against GPR33 could matter depends on whether native GPR33 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR33 is annotated at the cell surface, where native GPR33 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR33 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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