Seroatlas · Human Serome Atlas

GPR32

Probable G-protein coupled receptor 32

Also known as: GPR32_HUMAN, RVDR1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75388
Gene: GPR32
Ensembl: ENSG00000142511
Chromosome: 19
Canonical length: 356 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene is intronless and encodes a member of the G-protein coupled receptor 1 family. The encoded protein binds to resolvin D1 and lipoxin A4 and has been linked to pulmonary inflammation. A related pseudogene has been identified on chromosome 19. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

356 residues, UniProt reviewed canonical sequence.

>O75388|GPR32
     1  MNGVSEGTRG CSDRQPGVLT RDRSCSRKMN SSGCLSEEVG SLRPLTVVIL SASIVVGVLG
    61  NGLVLWMTVF RMARTVSTVC FFHLALADFM LSLSLPIAMY YIVSRQWLLG EWACKLYITF
   121  VFLSYFASNC LLVFISVDRC ISVLYPVWAL NHRTVQRASW LAFGVWLLAA ALCSAHLKFR
   181  TTRKWNGCTH CYLAFNSDNE TAQIWIEGVV EGHIIGTIGH FLLGFLGPLA IIGTCAHLIR
   241  AKLLREGWVH ANRPKRLLLV LVSAFFIFWS PFNVVLLVHL WRRVMLKEIY HPRMLLILQA
   301  SFALGCVNSS LNPFLYVFVG RDFQEKFFQS LTSALARAFG EEEFLSSCPR GNAPRE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR32 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 55 nTPM
placenta: 1.6 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

extravillous trophoblasts: 8 nCPM
syncytiotrophoblasts: 2.7 nCPM
migrating cytotrophoblasts: 0.9 nCPM
early spermatids: 0.3 nCPM
cytotrophoblasts: 0.1 nCPM
hofbauer cells: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 0.3 nTPM
cerebral cortex: 0.2 nTPM
hippocampal formation: 0.2 nTPM
pons: 0.2 nTPM
white matter: 0.2 nTPM
amygdala: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.03
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR32 as an antibody target. Whether an autoantibody or antibody against GPR32 could matter depends on whether native GPR32 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR32 is annotated at the cell surface, where native GPR32 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR32 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...