Seroatlas · Human Serome Atlas

GPR31

12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor

Also known as: 12-HETER, GPR31_HUMAN, HETER1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00270
Gene: GPR31
Ensembl: ENSG00000120436
Chromosome: 6
Canonical length: 319 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Enables G protein-coupled receptor activity and arachidonate binding activity. Involved in G protein-coupled receptor signaling pathway and response to acidic pH. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

319 residues, UniProt reviewed canonical sequence.

>O00270|GPR31
     1  MPFPNCSAPS TVVATAVGVL LGLECGLGLL GNAVALWTFL FRVRVWKPYA VYLLNLALAD
    61  LLLAACLPFL AAFYLSLQAW HLGRVGCWAL HFLLDLSRSV GMAFLAAVAL DRYLRVVHPR
   121  LKVNLLSPQA ALGVSGLVWL LMVALTCPGL LISEAAQNST RCHSFYSRAD GSFSIIWQEA
   181  LSCLQFVLPF GLIVFCNAGI IRALQKRLRE PEKQPKLQRA QALVTLVVVL FALCFLPCFL
   241  ARVLMHIFQN LGSCRALCAV AHTSDVTGSL TYLHSVLNPV VYCFSSPTFR SSYRRVFHTL
   301  RGKGQAAEPP DFNPRDSYS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR31 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 1.3 nTPM

Expression across tissuesHPA

Tissue

lymph node: 1.3 nTPM
epididymis: 0.6 nTPM
spleen: 0.6 nTPM
tonsil: 0.4 nTPM
appendix: 0.3 nTPM
thymus: 0.3 nTPM

Single-cell type

cdc: 3.4 nCPM
epididymal principal cells: 1.3 nCPM
early primary spermatocytes: 0.9 nCPM
fallopian tube ciliated cells: 0.5 nCPM
macrophages: 0.4 nCPM
epididymal efferent duct absorptive cells: 0.3 nCPM

Immune cell

myeloid DC: 0.5 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0.02
gnomAD missense Z: -0.29
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPR31 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KRAS

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR31 as an antibody target. Whether an autoantibody or antibody against GPR31 could matter depends on whether native GPR31 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR31 is annotated at the cell surface, where native GPR31 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR31 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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