Seroatlas · Human Serome Atlas

GPR3

G-protein coupled receptor 3

Also known as: ACCA, GPR3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P46089
Gene: GPR3
Ensembl: ENSG00000181773
Chromosome: 1
Canonical length: 330 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins, Transporters
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates adenylate cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012]

Canonical amino-acid sequenceUniProt

330 residues, UniProt reviewed canonical sequence.

>P46089|GPR3
     1  MMWGAGSPLA WLSAGSGNVN VSSVGPAEGP TGPAAPLPSP KAWDVVLCIS GTLVSCENAL
    61  VVAIIVGTPA FRAPMFLLVG SLAVADLLAG LGLVLHFAAV FCIGSAEMSL VLVGVLAMAF
   121  TASIGSLLAI TVDRYLSLYN ALTYYSETTV TRTYVMLALV WGGALGLGLL PVLAWNCLDG
   181  LTTCGVVYPL SKNHLVVLAI AFFMVFGIML QLYAQICRIV CRHAQQIALQ RHLLPASHYV
   241  ATRKGIATLA VVLGAFAACW LPFTVYCLLG DAHSPPLYTY LTLLPATYNS MINPIIYAFR
   301  NQDVQKVLWA VCCCCSSSKI PFRSRSPSDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 5.2 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 5.2 nTPM
cerebral cortex: 4.4 nTPM
hypothalamus: 4.4 nTPM
pituitary gland: 4.2 nTPM
cerebellum: 3.5 nTPM
hippocampal formation: 3 nTPM

Single-cell type

paneth cells: 7.7 nCPM
megakaryocytes: 6.2 nCPM
epididymal basal cells: 5.3 nCPM
pancreatic islet cells: 3.3 nCPM
müller glia: 2.9 nCPM
neuroendocrine cells: 2.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 17 nTPM
cerebellum: 9.2 nTPM
medulla oblongata: 8.8 nTPM
pons: 8.7 nTPM
hypothalamus: 6.8 nTPM
midbrain: 6.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0
gnomAD missense Z: 0.94
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
G protein-coupled receptor 3/6/12 orphan
GPCR, rhodopsin-like, 7TM
7 transmembrane receptor (rhodopsin family)
G protein-coupled receptor 3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPR3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

GNAS

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR3 as an antibody target. Whether an autoantibody or antibody against GPR3 could matter depends on whether native GPR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR3 is annotated at the cell surface, where native GPR3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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