Seroatlas · Human Serome Atlas

GPR27

Probable G-protein coupled receptor 27

Also known as: GPR27_HUMAN, SREB1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NS67
Gene: GPR27
Ensembl: ENSG00000170837
Chromosome: 3
Canonical length: 375 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane,Actin filaments,Cytosol

OverviewNCBI Gene

GPR27 is a member of the G protein-coupled receptors (GPCRs), a large family of receptors that have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli such as neurotransmitters, hormones, or light induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins.[supplied by OMIM, May 2010]

Canonical amino-acid sequenceUniProt

375 residues, UniProt reviewed canonical sequence.

>Q9NS67|GPR27
     1  MANASEPGGS GGGEAAALGL KLATLSLLLC VSLAGNVLFA LLIVRERSLH RAPYYLLLDL
    61  CLADGLRALA CLPAVMLAAR RAAAAAGAPP GALGCKLLAF LAALFCFHAA FLLLGVGVTR
   121  YLAIAHHRFY AERLAGWPCA AMLVCAAWAL ALAAAFPPVL DGGGDDEDAP CALEQRPDGA
   181  PGALGFLLLL AVVVGATHLV YLRLLFFIHD RRKMRPARLV PAVSHDWTFH GPGATGQAAA
   241  NWTAGFGRGP TPPALVGIRP AGPGRGARRL LVLEEFKTEK RLCKMFYAVT LLFLLLWGPY
   301  VVASYLRVLV RPGAVPQAYL TASVWLTFAQ AGINPVVCFL FNRELRDCFR AQFPCCQSPR
   361  TTQATHPCDL KGIGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 36 nTPM
spinal cord: 33 nTPM
amygdala: 25 nTPM
hippocampal formation: 22 nTPM
hypothalamus: 21 nTPM
midbrain: 20 nTPM

Single-cell type

neutrophils: 123 nCPM
neutrophil progenitors: 25 nCPM
hematopoietic stem cells: 21 nCPM
monocyte progenitors: 20 nCPM
megakaryocyte progenitors: 20 nCPM
pancreatic islet cells: 18 nCPM

Immune cell

neutrophil: 7.3 nTPM
eosinophil: 2.8 nTPM
classical monocyte: 0.5 nTPM
naive CD4 T-cell: 0.2 nTPM
intermediate monocyte: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

hypothalamus: 39 nTPM
basal ganglia: 39 nTPM
amygdala: 36 nTPM
spinal cord: 33 nTPM
hippocampal formation: 33 nTPM
cerebral cortex: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0.35
gnomAD missense Z: 1.6
DepMap mean gene effect: 0.16
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

G protein-coupled receptor activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR27 as an antibody target. Whether an autoantibody or antibody against GPR27 could matter depends on whether native GPR27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR27 is annotated at the cell surface, where native GPR27 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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