GPR26
G-protein coupled receptor 26
Also known as: GPR26_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NDV2
- Gene
- GPR26
- Ensembl
- ENSG00000154478
- Chromosome
- 10
- Canonical length
- 337 aa
- Protein class
- G-protein coupled receptors, Predicted membrane proteins
OverviewNCBI Gene
This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas. [provided by RefSeq, Sep 2016]
Canonical amino-acid sequenceUniProt
337 residues, UniProt reviewed canonical sequence.
>Q8NDV2|GPR26
1 MNSWDAGLAG LLVGTMGVSL LSNALVLLCL LHSADIRRQA PALFTLNLTC GNLLCTVVNM
61 PLTLAGVVAQ RQPAGDRLCR LAAFLDTFLA ANSMLSMAAL SIDRWVAVVF PLSYRAKMRL
121 RDAALMVAYT WLHALTFPAA ALALSWLGFH QLYASCTLCS RRPDERLRFA VFTGAFHALS
181 FLLSFVVLCC TYLKVLKVAR FHCKRIDVIT MQTLVLLVDL HPSVRERCLE EQKRRRQRAT
241 KKISTFIGTF LVCFAPYVIT RLVELFSTVP IGSHWGVLSK CLAYSKAASD PFVYSLLRHQ
301 YRKSCKEILN RLLHRRSIHS SGLTGDSHSQ NILPVSELocalizationUniProt · AlphaFold · HPA
Whether an antibody against GPR26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.29
- Highest tissue expression
- 4.2 nTPM
Expression across tissuesHPA
Tissue
- midbrain: 4.2 nTPM
- cerebral cortex: 3.5 nTPM
- hippocampal formation: 3.2 nTPM
- hypothalamus: 1.8 nTPM
- amygdala: 1.3 nTPM
- blood vessel: 0.3 nTPM
Single-cell type
- retinal amacrine cells: 7.8 nCPM
- brain excitatory neurons: 6.7 nCPM
- other brain neurons: 4.9 nCPM
- oocytes: 4.6 nCPM
- retinal horizontal cells: 4 nCPM
- brain inhibitory neurons: 2.7 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- midbrain: 19 nTPM
- hippocampal formation: 16 nTPM
- cerebral cortex: 10 nTPM
- thalamus: 9.4 nTPM
- medulla oblongata: 7.6 nTPM
- hypothalamus: 6.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.59
- gnomAD pLI
- 0.52
- gnomAD missense Z
- 2.61
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GPR26 as an antibody target. Whether an autoantibody or antibody against GPR26 could matter depends on whether native GPR26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GPR26 is annotated at the cell surface, where native GPR26 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label GPR26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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