Seroatlas · Human Serome Atlas

GPR22

G-protein coupled receptor 22

Also known as: GPR22_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99680
Gene: GPR22
Ensembl: ENSG00000172209
Chromosome: 7
Canonical length: 433 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

433 residues, UniProt reviewed canonical sequence.

>Q99680|GPR22
     1  MCFSPILEIN MQSESNITVR DDIDDINTNM YQPLSYPLSF QVSLTGFLML EIVLGLGSNL
    61  TVLVLYCMKS NLINSVSNII TMNLHVLDVI ICVGCIPLTI VILLLSLESN TALICCFHEA
   121  CVSFASVSTA INVFAITLDR YDISVKPANR ILTMGRAVML MISIWIFSFF SFLIPFIEVN
   181  FFSLQSGNTW ENKTLLCVST NEYYTELGMY YHLLVQIPIF FFTVVVMLIT YTKILQALNI
   241  RIGTRFSTGQ KKKARKKKTI SLTTQHEATD MSQSSGGRNV VFGVRTSVSV IIALRRAVKR
   301  HRERRERQKR VFRMSLLIIS TFLLCWTPIS VLNTTILCLG PSDLLVKLRL CFLVMAYGTT
   361  IFHPLLYAFT RQKFQKVLKS KMKKRVVSIV EADPLPNNAV IHNSWIDPKR NKKITFEDSE
   421  IREKCLVPQV VTD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 7.7 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 7.7 nTPM
cerebral cortex: 6.5 nTPM
cerebellum: 4.6 nTPM
hippocampal formation: 3.3 nTPM
cervix: 2.3 nTPM
amygdala: 1.8 nTPM

Single-cell type

brain excitatory neurons: 42 nCPM
brain inhibitory neurons: 24 nCPM
other brain neurons: 12 nCPM
cardiomyocytes: 8.5 nCPM
oligodendrocyte progenitor cells: 8.2 nCPM
epicardial cells: 6.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 9.4 nTPM
cerebral cortex: 9.4 nTPM
hippocampal formation: 7.6 nTPM
basal ganglia: 7 nTPM
white matter: 6.4 nTPM
amygdala: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0.06
gnomAD missense Z: 2.07
DepMap mean gene effect: 0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

G protein-coupled receptor activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR22 as an antibody target. Whether an autoantibody or antibody against GPR22 could matter depends on whether native GPR22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR22 is annotated at the cell surface, where native GPR22 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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