Seroatlas · Human Serome Atlas

GPR20

G-protein coupled receptor 20

Also known as: GPR20_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99678
Gene: GPR20
Ensembl: ENSG00000204882
Chromosome: 8
Canonical length: 358 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Enables G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in plasma membrane. Part of receptor complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

358 residues, UniProt reviewed canonical sequence.

>Q99678|GPR20
     1  MPSVSPAGPS AGAVPNATAV TTVRTNASGL EVPLFHLFAR LDEELHGTFP GLWLALMAVH
    61  GAIFLAGLVL NGLALYVFCC RTRAKTPSVI YTINLVVTDL LVGLSLPTRF AVYYGARGCL
   121  RCAFPHVLGY FLNMHCSILF LTCICVDRYL AIVRPEGSRR CRQPACARAV CAFVWLAAGA
   181  VTLSVLGVTG SRPCCRVFAL TVLEFLLPLL VISVFTGRIM CALSRPGLLH QGRQRRVRAM
   241  QLLLTVLIIF LVCFTPFHAR QVAVALWPDM PHHTSLVVYH VAVTLSSLNS CMDPIVYCFV
   301  TSGFQATVRG LFGQHGEREP SSGDVVSMHR SSKGSGRHHI LSAGPHALTQ ALANGPEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 4.1 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 4.1 nTPM
endometrium: 2.1 nTPM
small intestine: 2.1 nTPM
cervix: 1.8 nTPM
smooth muscle: 1.7 nTPM
fallopian tube: 1.6 nTPM

Single-cell type

vascular smooth muscle cells: 7.4 nCPM
monocytes: 2.6 nCPM
pericytes: 0.9 nCPM
podocytes: 0.5 nCPM
papillary tip epithelial cells: 0.2 nCPM
brain excitatory neurons: 0.1 nCPM

Immune cell

non-classical monocyte: 4.3 nTPM
intermediate monocyte: 2.6 nTPM
myeloid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebral cortex: 1.4 nTPM
pons: 0.7 nTPM
choroid plexus: 0.6 nTPM
thalamus: 0.6 nTPM
basal ganglia: 0.5 nTPM
medulla oblongata: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0.44
gnomAD missense Z: 0.75
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

G protein-coupled receptor signaling pathway

Molecular functions

G protein-coupled receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR20 as an antibody target. Whether an autoantibody or antibody against GPR20 could matter depends on whether native GPR20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR20 is annotated at the cell surface, where native GPR20 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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