Seroatlas · Human Serome Atlas

GPR183

G-protein coupled receptor 183

Also known as: EBI2, GP183_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P32249
Gene: GPR183
Ensembl: ENSG00000169508
Chromosome: 13
Canonical length: 361 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Plasma membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

361 residues, UniProt reviewed canonical sequence.

>P32249|GPR183
     1  MDIQMANNFT PPSATPQGND CDLYAHHSTA RIVMPLHYSL VFIIGLVGNL LALVVIVQNR
    61  KKINSTTLYS TNLVISDILF TTALPTRIAY YAMGFDWRIG DALCRITALV FYINTYAGVN
   121  FMTCLSIDRF IAVVHPLRYN KIKRIEHAKG VCIFVWILVF AQTLPLLINP MSKQEAERIT
   181  CMEYPNFEET KSLPWILLGA CFIGYVLPLI IILICYSQIC CKLFRTAKQN PLTEKSGVNK
   241  KALNTIILII VVFVLCFTPY HVAIIQHMIK KLRFSNFLEC SQRHSFQISL HFTVCLMNFN
   301  CCMDPFIYFF ACKGYKRKVM RMLKRQVSVS ISSAVKSAPE ENSREMTETQ MMIHSKSSNG
   361  K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR183 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 106 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 106 nTPM
appendix: 80 nTPM
tonsil: 71 nTPM
lymph node: 63 nTPM
urinary bladder: 49 nTPM
gallbladder: 38 nTPM

Single-cell type

cdc: 1,208 nCPM
pdcs: 915 nCPM
monocytes: 811 nCPM
macrophages: 786 nCPM
b-cells: 302 nCPM
t-cells: 231 nCPM

Immune cell

basophil: 1,054 nTPM
NK-cell: 488 nTPM
memory CD4 T-cell: 464 nTPM
T-reg: 403 nTPM
eosinophil: 393 nTPM
memory B-cell: 365 nTPM

Brain region

medulla oblongata: 19 nTPM
white matter: 17 nTPM
choroid plexus: 17 nTPM
hypothalamus: 14 nTPM
spinal cord: 10 nTPM
thalamus: 9.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0.02
gnomAD missense Z: 1.27
DepMap mean gene effect: 0.16
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR183 as an antibody target. Whether an autoantibody or antibody against GPR183 could matter depends on whether native GPR183 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR183 is annotated at the cell surface, where native GPR183 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR183 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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