Seroatlas · Human Serome Atlas

GPR182

G-protein coupled receptor 182

Also known as: ADMR, AM-R, G10D, GP182_HUMAN, hrhAMR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15218
Gene: GPR182
Ensembl: ENSG00000166856
Chromosome: 12
Canonical length: 404 aa
Protein class: G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. This gene encodes a seven-transmembrane protein that belongs to the family 1 of G-protein coupled receptors. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

404 residues, UniProt reviewed canonical sequence.

>O15218|GPR182
     1  MSVKPSWGPG PSEGVTAVPT SDLGEIHNWT ELLDLFNHTL SECHVELSQS TKRVVLFALY
    61  LAMFVVGLVE NLLVICVNWR GSGRAGLMNL YILNMAIADL GIVLSLPVWM LEVTLDYTWL
   121  WGSFSCRFTH YFYFVNMYSS IFFLVCLSVD RYVTLTSASP SWQRYQHRVR RAMCAGIWVL
   181  SAIIPLPEVV HIQLVEGPEP MCLFMAPFET YSTWALAVAL STTILGFLLP FPLITVFNVL
   241  TACRLRQPGQ PKSRRHCLLL CAYVAVFVMC WLPYHVTLLL LTLHGTHISL HCHLVHLLYF
   301  FYDVIDCFSM LHCVINPILY NFLSPHFRGR LLNAVVHYLP KDQTKAGTCA SSSSCSTQHS
   361  IIITKGDSQP AAAAPHPEPS LSFQAHHLLP NTSPISPTQP LTPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR182 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

spleen: 16 nTPM
testis: 5.8 nTPM
liver: 3.7 nTPM
adrenal gland: 3 nTPM
kidney: 1.5 nTPM
lymph node: 1.4 nTPM

Single-cell type

late spermatids: 265 nCPM
early spermatids: 98 nCPM
lymphatic endothelial cells: 40 nCPM
adrenal medulla cells: 21 nCPM
hepatic stellate cells: 6.5 nCPM
late primary spermatocytes: 4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 2.3 nTPM
amygdala: 2 nTPM
cerebral cortex: 1.9 nTPM
hippocampal formation: 1.9 nTPM
white matter: 1.9 nTPM
basal ganglia: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: 0.18
DepMap mean gene effect: -0.13
DepMap dependency class: selective

OntologyGO

Biological processes

cell surface receptor signaling pathway

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPR182 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ABHD12

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR182 as an antibody target. Whether an autoantibody or antibody against GPR182 could matter depends on whether native GPR182 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR182 is annotated at the cell surface, where native GPR182 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR182 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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