Seroatlas · Human Serome Atlas

GPR180

Integral membrane protein GPR180

Also known as: GP180_HUMAN, ITR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86V85
Gene: GPR180
Ensembl: ENSG00000152749
Chromosome: 13
Canonical length: 440 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Vesicles,Primary cilium,Aggresome

OverviewNCBI Gene

This gene encodes a protein that is a member of the G protein-coupled receptor superfamily. This protein is produced predominantly in vascular smooth muscle cells and may play an important role in the regulation of vascular remodeling. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

440 residues, UniProt reviewed canonical sequence.

>Q86V85|GPR180
     1  MGGLRLLAVA LTCCWWPQGS QGKTLRGSFS STAAQDAQGQ RIGHFEFHGD HALLCVRINN
    61  IAVAVGKEAK LYLFQAQEWL KLQQSSHGYS CSEKLSKAQL TMTMNQTEHN LTVSQIPSPQ
   121  TWHVFYADKY TCQDDKENSQ VEDIPFEMVL LNPDAEGNPF DHFSAGESGL HEFFFLLVLV
   181  YFVIACIYAQ SLWQAIKKGG PMHMILKVLT TALLLQAGSA LANYIHFSSY SKDGIGVPFM
   241  GSLAEFFDIA SQIQMLYLLL SLCMGWTIVR MKKSQSRPLQ WDSTPASTGI AVFIVMTQSV
   301  LLLWEQFEDI SHHSYHSHHN LAGILLIVLR ICLALSLGCG LYQIITVERS TLKREFYITF
   361  AKGCILWFLC HPVLACISVI FSDYQRDKVI TIGVILCQSV SMVILYRLFL SHSLYWEVSS
   421  LSSVTLPLTI SSGHKSRPHF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR180 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 6.5 nTPM

Expression across tissuesHPA

Tissue

retina: 6.5 nTPM
liver: 6.4 nTPM
adipose tissue: 5.4 nTPM
cerebellum: 4.2 nTPM
spinal cord: 3.6 nTPM
placenta: 3.4 nTPM

Single-cell type

lactotrophs: 64 nCPM
gonadotrophs: 63 nCPM
corticotrophs: 62 nCPM
retinal pigment epithelial cells: 60 nCPM
adipocytes: 57 nCPM
rod photoreceptor cells: 56 nCPM

Immune cell

MAIT T-cell: 1.4 nTPM
T-reg: 1.2 nTPM
naive CD4 T-cell: 1.1 nTPM
memory CD4 T-cell: 0.9 nTPM
myeloid DC: 0.9 nTPM
naive CD8 T-cell: 0.9 nTPM

Brain region

cerebellum: 10 nTPM
choroid plexus: 9.7 nTPM
cerebral cortex: 9.6 nTPM
spinal cord: 8.6 nTPM
white matter: 8.4 nTPM
basal ganglia: 8.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: 0.76
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR180 as an antibody target. Whether an autoantibody or antibody against GPR180 could matter depends on whether native GPR180 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR180 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPR180 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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