Seroatlas · Human Serome Atlas

GPR176

G-protein coupled receptor 176

Also known as: Gm1012, GP176_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14439
Gene: GPR176
Ensembl: ENSG00000166073
Chromosome: 15
Canonical length: 515 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Members of the G protein-coupled receptor family, such as GPR176, are cell surface receptors involved in responses to hormones, growth factors, and neurotransmitters (Hata et al., 1995 [PubMed 7893747]).[supplied by OMIM, Jul 2008]

Canonical amino-acid sequenceUniProt

515 residues, UniProt reviewed canonical sequence.

>Q14439|GPR176
     1  MGHNGSWISP NASEPHNASG AEAAGVNRSA LGEFGEAQLY RQFTTTVQVV IFIGSLLGNF
    61  MVLWSTCRTT VFKSVTNRFI KNLACSGICA SLVCVPFDII LSTSPHCCWW IYTMLFCKVV
   121  KFLHKVFCSV TILSFPAIAL DRYYSVLYPL ERKISDAKSR ELVMYIWAHA VVASVPVFAV
   181  TNVADIYATS TCTEVWSNSL GHLVYVLVYN ITTVIVPVVV VFLFLILIRR ALSASQKKKV
   241  IIAALRTPQN TISIPYASQR EAELHATLLS MVMVFILCSV PYATLVVYQT VLNVPDTSVF
   301  LLLTAVWLPK VSLLANPVLF LTVNKSVRKC LIGTLVQLHH RYSRRNVVST GSGMAEASLE
   361  PSIRSGSQLL EMFHIGQQQI FKPTEDEEES EAKYIGSADF QAKEIFSTCL EGEQGPQFAP
   421  SAPPLSTVDS VSQVAPAAPV EPETFPDKYS LQFGFGPFEL PPQWLSETRN SKKRLLPPLG
   481  NTPEELIQTK VPKVGRVERK MSRNNKVSIF PKVDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR176 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 35 nTPM
cerebellum: 22 nTPM
basal ganglia: 18 nTPM
cerebral cortex: 15 nTPM
hypothalamus: 13 nTPM
adipose tissue: 12 nTPM

Single-cell type

hepatic stellate cells: 110 nCPM
adrenal medulla cells: 96 nCPM
somatotrophs: 82 nCPM
salivary myoepithelial cells: 80 nCPM
pericytes: 60 nCPM
retinal amacrine cells: 60 nCPM

Immune cell

eosinophil: 0.4 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 27 nTPM
cerebellum: 23 nTPM
hypothalamus: 22 nTPM
basal ganglia: 22 nTPM
cerebral cortex: 22 nTPM
midbrain: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0.01
gnomAD missense Z: 1.3
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

G protein-coupled receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
7 transmembrane receptor (rhodopsin family)
G protein-coupled receptor 176, rhodopsin-like, 7TM

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR176 as an antibody target. Whether an autoantibody or antibody against GPR176 could matter depends on whether native GPR176 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR176 is annotated at the cell surface, where native GPR176 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR176 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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