Seroatlas · Human Serome Atlas

GPR173

Probable G-protein coupled receptor 173

Also known as: GP173_HUMAN, SREB3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NS66
Gene: GPR173
Ensembl: ENSG00000184194
Chromosome: X
Canonical length: 373 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the G-protein coupled receptor 1 family. This protein contains 7 transmembrane domains and conserved cysteine residues. [provided by RefSeq, Nov 2009]

Canonical amino-acid sequenceUniProt

373 residues, UniProt reviewed canonical sequence.

>Q9NS66|GPR173
     1  MANTTGEPEE VSGALSPPSA SAYVKLVLLG LIMCVSLAGN AILSLLVLKE RALHKAPYYF
    61  LLDLCLADGI RSAVCFPFVL ASVRHGSSWT FSALSCKIVA FMAVLFCFHA AFMLFCISVT
   121  RYMAIAHHRF YAKRMTLWTC AAVICMAWTL SVAMAFPPVF DVGTYKFIRE EDQCIFEHRY
   181  FKANDTLGFM LMLAVLMAAT HAVYGKLLLF EYRHRKMKPV QMVPAISQNW TFHGPGATGQ
   241  AAANWIAGFG RGPMPPTLLG IRQNGHAASR RLLGMDEVKG EKQLGRMFYA ITLLFLLLWS
   301  PYIVACYWRV FVKACAVPHR YLATAVWMSF AQAAVNPIVC FLLNKDLKKC LRTHAPCWGT
   361  GGAPAPREPY CVM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR173 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 17 nTPM
pituitary gland: 17 nTPM
ovary: 11 nTPM
hypothalamus: 11 nTPM
cerebral cortex: 10 nTPM
basal ganglia: 9.6 nTPM

Single-cell type

lactotrophs: 142 nCPM
astrocytes: 100 nCPM
somatotrophs: 99 nCPM
bergmann glia: 91 nCPM
pituicytes/fscs: 90 nCPM
peritubular myoid cells: 86 nCPM

Immune cell

basophil: 3.9 nTPM
NK-cell: 0.8 nTPM
neutrophil: 0.7 nTPM
gdT-cell: 0.4 nTPM
naive B-cell: 0.4 nTPM
MAIT T-cell: 0.2 nTPM

Brain region

hypothalamus: 34 nTPM
cerebellum: 34 nTPM
midbrain: 33 nTPM
pons: 32 nTPM
cerebral cortex: 30 nTPM
amygdala: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0.87
gnomAD missense Z: 2.26
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR173 as an antibody target. Whether an autoantibody or antibody against GPR173 could matter depends on whether native GPR173 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR173 is annotated at the cell surface, where native GPR173 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR173 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...