Seroatlas · Human Serome Atlas

GPR171

G-protein coupled receptor 171

Also known as: GP171_HUMAN, H963

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14626
Gene: GPR171
Ensembl: ENSG00000174946
Chromosome: 3
Canonical length: 319 aa
Protein class: G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles,Plasma membrane

OverviewNCBI Gene

Predicted to enable G protein-coupled purinergic nucleotide receptor activity; neuropeptide binding activity; and neuropeptide receptor activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway; regulation of feeding behavior; and regulation of sensory perception of pain. Predicted to act upstream of or within negative regulation of myeloid cell differentiation. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

319 residues, UniProt reviewed canonical sequence.

>O14626|GPR171
     1  MTNSSFFCPV YKDLEPFTYF FYLVFLVGII GSCFATWAFI QKNTNHRCVS IYLINLLTAD
    61  FLLTLALPVK IVVDLGVAPW KLKIFHCQVT ACLIYINMYL SIIFLAFVSI DRCLQLTHSC
   121  KIYRIQEPGF AKMISTVVWL MVLLIMVPNM MIPIKDIKEK SNVGCMEFKK EFGRNWHLLT
   181  NFICVAIFLN FSAIILISNC LVIRQLYRNK DNENYPNVKK ALINILLVTT GYIICFVPYH
   241  IVRIPYTLSQ TEVITDCSTR ISLFKAKEAT LLLAVSNLCF DPILYYHLSK AFRSKVTETF
   301  ASPKETKAQK EKLRCENNA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR171 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

appendix: 20 nTPM
lymph node: 16 nTPM
spleen: 12 nTPM
thymus: 12 nTPM
small intestine: 12 nTPM
tonsil: 11 nTPM

Single-cell type

t-cells: 144 nCPM
nk-cells: 44 nCPM
innate lymphoid cells: 32 nCPM
hematopoietic stem cells: 16 nCPM
megakaryocyte progenitors: 14 nCPM
müller glia: 12 nCPM

Immune cell

MAIT T-cell: 111 nTPM
memory CD8 T-cell: 54 nTPM
memory CD4 T-cell: 40 nTPM
gdT-cell: 28 nTPM
naive CD4 T-cell: 24 nTPM
T-reg: 22 nTPM

Brain region

choroid plexus: 35 nTPM
cerebral cortex: 17 nTPM
medulla oblongata: 13 nTPM
cerebellum: 13 nTPM
basal ganglia: 12 nTPM
thalamus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: 1.2
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
7 transmembrane receptor (rhodopsin family)
G-protein-coupled receptor 171

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR171 as an antibody target. Whether an autoantibody or antibody against GPR171 could matter depends on whether native GPR171 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR171 is annotated at the cell surface, where native GPR171 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR171 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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