Seroatlas · Human Serome Atlas

GPR162

Probable G-protein coupled receptor 162

Also known as: A-2, GP162_HUMAN, GRCA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16538
Gene: GPR162
Ensembl: ENSG00000250510
Chromosome: 12
Canonical length: 588 aa
Protein class: G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Centriolar satellite
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene was identified upon genomic analysis of a gene-dense region at human chromosome 12p13. It appears to be mainly expressed in the brain; however, its function is not known. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

588 residues, UniProt reviewed canonical sequence.

>Q16538|GPR162
     1  MARGGAGAEE ASLRSNALSW LACGLLALLA NAWIILSISA KQQKHKPLEL LLCFLAGTHI
    61  LMAAVPLTTF AVVQLRRQAS SDYDWNESIC KVFVSTYYTL ALATCFTVAS LSYHRMWMVR
   121  WPVNYRLSNA KKQALHAVMG IWMVSFILST LPSIGWHNNG ERYYARGCQF IVSKIGLGFG
   181  VCFSLLLLGG IVMGLVCVAI TFYQTLWARP RRARQARRVG GGGGTKAGGP GALGTRPAFE
   241  VPAIVVEDAR GKRRSSLDGS ESAKTSLQVT NLVSAIVFLY DSLTGVPILV VSFFSLKSDS
   301  APPWMVLAVL WCSMAQTLLL PSFIWSCERY RADVRTVWEQ CVAIMSEEDG DDDGGCDDYA
   361  EGRVCKVRFD ANGATGPGSR DPAQVKLLPG RHMLFPPLER VHYLQVPLSR RLSHDETNIF
   421  STPREPGSFL HKWSSSDDIR VLPAQSRALG GPPEYLGQRH RLEDEEDEEE AEGGGLASLR
   481  QFLESGVLGS GGGPPRGPGF FREEITTFID ETPLPSPTAS PGHSPRRPRP LGLSPRRLSL
   541  GSPESRAVGL PLGLSAGRRC SLTGGEESAR AWGGSWGPGN PIFPQLTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR162 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 144 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 144 nTPM
cerebral cortex: 120 nTPM
hippocampal formation: 100 nTPM
choroid plexus: 73 nTPM
amygdala: 70 nTPM
hypothalamus: 65 nTPM

Single-cell type

respiratory ciliated cells: 114 nCPM
fallopian tube ciliated cells: 69 nCPM
ependymal cells: 59 nCPM
retinal amacrine cells: 55 nCPM
retinal bipolar cells: 48 nCPM
brain excitatory neurons: 44 nCPM

Immune cell

neutrophil: 18 nTPM
classical monocyte: 6.9 nTPM
intermediate monocyte: 4.3 nTPM
myeloid DC: 2 nTPM
total PBMC: 1.9 nTPM
plasmacytoid DC: 1.7 nTPM

Brain region

cerebral cortex: 139 nTPM
hippocampal formation: 131 nTPM
white matter: 85 nTPM
basal ganglia: 85 nTPM
cerebellum: 75 nTPM
amygdala: 74 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.66
gnomAD pLI: 0.01
gnomAD missense Z: 0.89
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

G protein-coupled receptor activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
G protein-coupled receptor 153/162
7 transmembrane receptor (rhodopsin family)
G protein-coupled receptor 162

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR162 as an antibody target. Whether an autoantibody or antibody against GPR162 could matter depends on whether native GPR162 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR162 is annotated at the cell surface, where native GPR162 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR162 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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