Seroatlas · Human Serome Atlas

GPR161

G-protein coupled receptor 161

Also known as: GP161_HUMAN, RE2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N6U8
Gene: GPR161
Ensembl: ENSG00000143147
Chromosome: 1
Canonical length: 529 aa
Protein class: Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location: Primary cilium,Primary cilium transition zone

OverviewNCBI Gene

The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast cancer, and disruption of this gene slows the proliferation of basal breast cancer cells. Therefore, this gene is a potential drug target for triple-negative breast cancer. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

529 residues, UniProt reviewed canonical sequence.

>Q8N6U8|GPR161
     1  MSLNSSLSCR KELSNLTEEE GGEGGVIITQ FIAIIVITIF VCLGNLVIVV TLYKKSYLLT
    61  LSNKFVFSLT LSNFLLSVLV LPFVVTSSIR REWIFGVVWC NFSALLYLLI SSASMLTLGV
   121  IAIDRYYAVL YPMVYPMKIT GNRAVMALVY IWLHSLIGCL PPLFGWSSVE FDEFKWMCVA
   181  AWHREPGYTA FWQIWCALFP FLVMLVCYGF IFRVARVKAR KVHCGTVVIV EEDAQRTGRK
   241  NSSTSTSSSG SRRNAFQGVV YSANQCKALI TILVVLGAFM VTWGPYMVVI ASEALWGKSS
   301  VSPSLETWAT WLSFASAVCH PLIYGLWNKT VRKELLGMCF GDRYYREPFV QRQRTSRLFS
   361  ISNRITDLGL SPHLTALMAG GQPLGHSSST GDTGFSCSQD SGTDMMLLED YTSDDNPPSH
   421  CTCPPKRRSS VTFEDEVEQI KEAAKNSILH VKAEVHKSLD SYAASLAKAI EAEAKINLFG
   481  EEALPGVLVT ARTVPGGGFG GRRGSRTLVS QRLQLQSIEE GDVLAAEQR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR161 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

smooth muscle: 26 nTPM
endometrium: 24 nTPM
seminal vesicle: 11 nTPM
pancreas: 11 nTPM
esophagus: 9.2 nTPM
prostate: 8.9 nTPM

Single-cell type

retinal horizontal cells: 100 nCPM
smooth muscle cells: 36 nCPM
podocytes: 36 nCPM
vascular smooth muscle cells: 28 nCPM
astrocytes: 27 nCPM
endometrial stromal cells: 26 nCPM

Immune cell

basophil: 0.2 nTPM
myeloid DC: 0.1 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

midbrain: 22 nTPM
thalamus: 11 nTPM
cerebral cortex: 10 nTPM
amygdala: 10 nTPM
pons: 10 nTPM
medulla oblongata: 9.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GPR161.

Disease | AllUniProt

Conditions GPR161 is implicated in, by any mechanism.

Medulloblastoma (MDB) MIM:155255

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 185 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Medulloblastoma

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0
gnomAD missense Z: 1.51
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

adenylate cyclase-activating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

Molecular functions

G protein-coupled receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR161 as an antibody target. Whether an autoantibody or antibody against GPR161 could matter depends on whether native GPR161 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR161 is annotated at the cell surface, where native GPR161 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR161 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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