GPR160
Probable G-protein coupled receptor 160
Also known as: GP160_HUMAN, GPCR1, GPCR150
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UJ42
- Gene
- GPR160
- Ensembl
- ENSG00000173890
- Chromosome
- 3
- Canonical length
- 338 aa
- Protein class
- G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters
- Subcellular location
- Plasma membrane
OverviewNCBI Gene
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in plasma membrane. Part of receptor complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
338 residues, UniProt reviewed canonical sequence.
>Q9UJ42|GPR160
1 MTALSSENCS FQYQLRQTNQ PLDVNYLLFL IILGKILLNI LTLGMRRKNT CQNFMEYFCI
61 SLAFVDLLLL VNISIILYFR DFVLLSIRFT KYHICLFTQI ISFTYGFLHY PVFLTACIDY
121 CLNFSKTTKL SFKCQKLFYF FTVILIWISV LAYVLGDPAI YQSLKAQNAY SRHCPFYVSI
181 QSYWLSFFMV MILFVAFITC WEEVTTLVQA IRITSYMNET ILYFPFSSHS SYTVRSKKIF
241 LSKLIVCFLS TWLPFVLLQV IIVLLKVQIP AYIEMNIPWL YFVNSFLIAT VYWFNCHKLN
301 LKDIGLPLDP FVNWKCCFIP LTIPNLEQIE KPISIMICLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GPR160 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.34
- Highest tissue expression
- 204 nTPM
Expression across tissuesHPA
Tissue
- parathyroid gland: 204 nTPM
- bone marrow: 102 nTPM
- retina: 97 nTPM
- small intestine: 93 nTPM
- duodenum: 69 nTPM
- rectum: 68 nTPM
Single-cell type
- rod photoreceptor cells: 675 nCPM
- neutrophils: 407 nCPM
- enterocytes: 406 nCPM
- gastric chief cells: 339 nCPM
- enteric stem cells: 294 nCPM
- neuroendocrine cells: 278 nCPM
Immune cell
- naive B-cell: 12 nTPM
- neutrophil: 11 nTPM
- eosinophil: 9.3 nTPM
- memory B-cell: 8 nTPM
- plasmacytoid DC: 3.2 nTPM
- naive CD4 T-cell: 3 nTPM
Brain region
- cerebral cortex: 5.7 nTPM
- medulla oblongata: 5.4 nTPM
- pons: 4.6 nTPM
- white matter: 4.6 nTPM
- basal ganglia: 4.3 nTPM
- cerebellum: 4.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.26
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.21
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- GPCR, rhodopsin-like, 7TM
- Probable G-protein coupled receptor 160
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GPR160 as an antibody target. Whether an autoantibody or antibody against GPR160 could matter depends on whether native GPR160 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GPR160 is annotated at the cell surface, where native GPR160 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label GPR160 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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