Seroatlas · Human Serome Atlas

GPR15LG

Protein GPR15LG

Also known as: AP-57, C10orf99, CSBF, FLJ21763, GP15L_HUMAN, GPR15L, RLLV1833, UNQ1833

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UWK7
Gene: GPR15LG
Ensembl: ENSG00000188373
Chromosome: 10
Canonical length: 81 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Enables chemokine activity. Involved in several processes, including defense response to other organism; mast cell degranulation; and negative regulation of cell cycle G1/S phase transition. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

81 residues, UniProt reviewed canonical sequence.

>Q6UWK7|GPR15LG
     1  MRLLVLSSLL CILLLCFSIF STEGKRRPAK AWSGRRTRLC CHRVPSPNST NLKGHHVRLC
    61  KPCKLEPEPR LWVVPGALPQ V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR15LG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 258 nTPM

Expression across tissuesHPA

Tissue

rectum: 258 nTPM
colon: 251 nTPM
esophagus: 205 nTPM
vagina: 123 nTPM
cervix: 94 nTPM
skin: 40 nTPM

Single-cell type

esophageal suprabasal cells: 2,234 nCPM
colonocytes: 963 nCPM
esophageal apical cells: 627 nCPM
esophageal basal cells: 400 nCPM
enteric transient amplifying cells: 394 nCPM
enterocytes: 328 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0.21
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

G-protein coupled receptor ligand 15
G-protein coupled receptor ligand 15

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPR15LG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SUSD2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR15LG as an antibody target. Whether an autoantibody or antibody against GPR15LG could matter depends on whether native GPR15LG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR15LG is annotated as secreted, so native GPR15LG circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label GPR15LG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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