GPR153

Protein identityUniProt · HPA

UniProt accession

Q6NV75

Gene

GPR153

Ensembl

ENSG00000158292

Chromosome

1

Canonical length

609 aa

Protein class

G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associated with a significant reduction in food intake and impaired decision making ability. Mutations in this gene are associated with schizophrenia, autism, and other neuropsychiatric disorders. The expression of this gene is activated by the glioma-associated oncogene homolog 1 transcription factor which, in turn, is activated by sonic hedgehog in normal and tumorigenic cells. [provided by RefSeq, Feb 2017]

Canonical amino-acid sequenceUniProt

609 residues, UniProt reviewed canonical sequence.

>Q6NV75|GPR153
     1  MSDERRLPGS AVGWLVCGGL SLLANAWGIL SVGAKQKKWK PLEFLLCTLA ATHMLNVAVP
    61  IATYSVVQLR RQRPDFEWNE GLCKVFVSTF YTLTLATCFS VTSLSYHRMW MVCWPVNYRL
   121  SNAKKQAVHT VMGIWMVSFI LSALPAVGWH DTSERFYTHG CRFIVAEIGL GFGVCFLLLV
   181  GGSVAMGVIC TAIALFQTLA VQVGRQADRR AFTVPTIVVE DAQGKRRSSI DGSEPAKTSL
   241  QTTGLVTTIV FIYDCLMGFP VLVVSFSSLR ADASAPWMAL CVLWCSVAQA LLLPVFLWAC
   301  DRYRADLKAV REKCMALMAN DEESDDETSL EGGISPDLVL ERSLDYGYGG DFVALDRMAK
   361  YEISALEGGL PQLYPLRPLQ EDKMQYLQVP PTRRFSHDDA DVWAAVPLPA FLPRWGSGED
   421  LAALAHLVLP AGPERRRASL LAFAEDAPPS RARRRSAESL LSLRPSALDS GPRGARDSPP
   481  GSPRRRPGPG PRSASASLLP DAFALTAFEC EPQALRRPPG PFPAAPAAPD GADPGEAPTP
   541  PSSAQRSPGP RPSAHSHAGS LRPGLSASWG EPGGLRAAGG GGSTSSFLSS PSESSGYATL
   601  HSDSLGSAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR153 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.49

Highest tissue expression

20 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GPR153.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 149 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Childhood-onset schizophrenia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.29

gnomAD pLI

0

gnomAD missense Z

0.67

DepMap mean gene effect

-0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

• G protein-coupled receptor activity

Cellular components

• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• G protein-coupled receptor, rhodopsin-like
• GPCR, rhodopsin-like, 7TM
• G protein-coupled receptor 153/162
• 7 transmembrane receptor (rhodopsin family)
• G protein-coupled receptor 153

KeywordsUniProt

• Cell membrane
• G-protein coupled receptor
• Membrane
• Receptor
• Transducer
• Transmembrane
• Transmembrane helix