Seroatlas · Human Serome Atlas

GPR152

Probable G-protein coupled receptor 152

Also known as: GP152_HUMAN, PGR5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TDT2
Gene: GPR152
Ensembl: ENSG00000175514
Chromosome: 11
Canonical length: 470 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

470 residues, UniProt reviewed canonical sequence.

>Q8TDT2|GPR152
     1  MDTTMEADLG ATGHRPRTEL DDEDSYPQGG WDTVFLVALL LLGLPANGLM AWLAGSQARH
    61  GAGTRLALLL LSLALSDFLF LAAAAFQILE IRHGGHWPLG TAACRFYYFL WGVSYSSGLF
   121  LLAALSLDRC LLALCPHWYP GHRPVRLPLW VCAGVWVLAT LFSVPWLVFP EAAVWWYDLV
   181  ICLDFWDSEE LSLRMLEVLG GFLPFLLLLV CHVLTQATAC RTCHRQQQPA ACRGFARVAR
   241  TILSAYVVLR LPYQLAQLLY LAFLWDVYSG YLLWEALVYS DYLILLNSCL SPFLCLMASA
   301  DLRTLLRSVL SSFAAALCEE RPGSFTPTEP QTQLDSEGPT LPEPMAEAQS QMDPVAQPQV
   361  NPTLQPRSDP TAQPQLNPTA QPQSDPTAQP QLNLMAQPQS DSVAQPQADT NVQTPAPAAS
   421  SVPSPCDEAS PTPSSHPTPG ALEDPATPPA SEGESPSSTP PEAAPGAGPT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR152 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 0.3 nTPM

Expression across tissuesHPA

Tissue

retina: 0.3 nTPM
small intestine: 0.2 nTPM
spleen: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

macrophages: 0.3 nCPM
vascular endothelial cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 0.2 nTPM
cerebral cortex: 0.2 nTPM
white matter: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
hippocampal formation: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.44
gnomAD pLI: 0
gnomAD missense Z: 0.84
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

G protein-coupled receptor signaling pathway

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR152 as an antibody target. Whether an autoantibody or antibody against GPR152 could matter depends on whether native GPR152 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR152 is annotated at the cell surface, where native GPR152 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR152 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...