GPR151

Protein identityUniProt · HPA

UniProt accession

Q8TDV0

Gene

GPR151

Ensembl

ENSG00000173250

Chromosome

5

Canonical length

419 aa

Protein class

G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the SOG subfamily that includes somatostatin, opioid, galanin, and kisspeptin receptors. The orthologous mouse gene has a restricted pattern of neuronal expression which is induced following nerve injury. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

419 residues, UniProt reviewed canonical sequence.

>Q8TDV0|GPR151
     1  MLAAAFADSN SSSMNVSFAH LHFAGGYLPS DSQDWRTIIP ALLVAVCLVG FVGNLCVIGI
    61  LLHNAWKGKP SMIHSLILNL SLADLSLLLF SAPIRATAYS KSVWDLGWFV CKSSDWFIHT
   121  CMAAKSLTIV VVAKVCFMYA SDPAKQVSIH NYTIWSVLVA IWTVASLLPL PEWFFSTIRH
   181  HEGVEMCLVD VPAVAEEFMS MFGKLYPLLA FGLPLFFASF YFWRAYDQCK KRGTKTQNLR
   241  NQIRSKQVTV MLLSIAIISA LLWLPEWVAW LWVWHLKAAG PAPPQGFIAL SQVLMFSISS
   301  ANPLIFLVMS EEFREGLKGV WKWMITKKPP TVSESQETPA GNSEGLPDKV PSPESPASIP
   361  EKEKPSSPSS GKGKTEKAEI PILPDVEQFW HERDTVPSVQ DNDPIPWEHE DQETGEGVK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR151 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

0.5 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.5

gnomAD pLI

0

gnomAD missense Z

0.14

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• G protein-coupled receptor signaling pathway
• positive regulation of immune response
• regulation of synaptic vesicle exocytosis
• response to acidic pH
• response to ischemia

Molecular functions

• G protein-coupled receptor activity
• identical protein binding

Cellular components

• cholinergic synapse
• plasma membrane
• presynaptic membrane
• synaptic vesicle membrane

Protein domainsUniProt · Pfam · InterPro

• G protein-coupled receptor, rhodopsin-like
• GPCR, rhodopsin-like, 7TM
• 7 transmembrane receptor (rhodopsin family)

KeywordsUniProt

• Cell membrane
• Disulfide bond
• G-protein coupled receptor
• Glycoprotein
• Membrane
• Receptor
• Transducer
• Transmembrane
• Transmembrane helix