Seroatlas · Human Serome Atlas

GPR150

Probable G-protein coupled receptor 150

Also known as: GP150_HUMAN, PGR11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGU9
Gene: GPR150
Ensembl: ENSG00000178015
Chromosome: 5
Canonical length: 434 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the vasopressin-like subfamily that also includes vasopressin and oxytocin receptors. The silencing of this gene, due to promoter methylation, is associated with ovarian cancer progression. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

434 residues, UniProt reviewed canonical sequence.

>Q8NGU9|GPR150
     1  MEDLFSPSIL PPAPNISVPI LLGWGLNLTL GQGAPASGPP SRRVRLVFLG VILVVAVAGN
    61  TTVLCRLCGG GGPWAGPKRR KMDFLLVQLA LADLYACGGT ALSQLAWELL GEPRAATGDL
   121  ACRFLQLLQA SGRGASAHLV VLIALERRRA VRLPHGRPLP ARALAALGWL LALLLALPPA
   181  FVVRGDSPSP LPPPPPPTSL QPGAPPAARA WPGERRCHGI FAPLPRWHLQ VYAFYEAVAG
   241  FVAPVTVLGV ACGHLLSVWW RHRPQAPAAA APWSASPGRA PAPSALPRAK VQSLKMSLLL
   301  ALLFVGCELP YFAARLAAAW SSGPAGDWEG EGLSAALRVV AMANSALNPF VYLFFQAGDC
   361  RLRRQLRKRL GSLCCAPQGG AEDEEGPRGH QALYRQRWPH PHYHHARREP LDEGGLRPPP
   421  PRPRPLPCSC ESAF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR150 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 6.5 nTPM

Expression across tissuesHPA

Tissue

pancreas: 6.5 nTPM
cerebral cortex: 2.5 nTPM
stomach: 1.5 nTPM
parathyroid gland: 1.2 nTPM
amygdala: 0.9 nTPM
adipose tissue: 0.8 nTPM

Single-cell type

extravillous trophoblasts: 8.5 nCPM
gastric chief cells: 6.6 nCPM
hofbauer cells: 6.4 nCPM
late primary spermatocytes: 5.8 nCPM
oocytes: 4.6 nCPM
early spermatids: 3.3 nCPM

Immune cell

memory CD4 T-cell: 0.6 nTPM
MAIT T-cell: 0.5 nTPM
NK-cell: 0.5 nTPM
naive CD4 T-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM
basophil: 0 nTPM

Brain region

basal ganglia: 7 nTPM
cerebral cortex: 7 nTPM
hypothalamus: 5.6 nTPM
white matter: 5.2 nTPM
amygdala: 4.7 nTPM
hippocampal formation: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0
gnomAD missense Z: 0.61
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

G protein-coupled receptor activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR150 as an antibody target. Whether an autoantibody or antibody against GPR150 could matter depends on whether native GPR150 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR150 is annotated at the cell surface, where native GPR150 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR150 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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