Seroatlas · Human Serome Atlas

GPR15

G-protein coupled receptor 15

Also known as: GPR15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P49685
Gene: GPR15
Ensembl: ENSG00000154165
Chromosome: 3
Canonical length: 360 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a G protein-coupled receptor that acts as a chemokine receptor for human immunodeficiency virus type 1 and 2. The encoded protein localizes to the cell membrane. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

360 residues, UniProt reviewed canonical sequence.

>P49685|GPR15
     1  MDPEETSVYL DYYYATSPNS DIRETHSHVP YTSVFLPVFY TAVFLTGVLG NLVLMGALHF
    61  KPGSRRLIDI FIINLAASDF IFLVTLPLWV DKEASLGLWR TGSFLCKGSS YMISVNMHCS
   121  VLLLTCMSVD RYLAIVWPVV SRKFRRTDCA YVVCASIWFI SCLLGLPTLL SRELTLIDDK
   181  PYCAEKKATP IKLIWSLVAL IFTFFVPLLS IVTCYCCIAR KLCAHYQQSG KHNKKLKKSI
   241  KIIFIVVAAF LVSWLPFNTF KFLAIVSGLR QEHYLPSAIL QLGMEVSGPL AFANSCVNPF
   301  IYYIFDSYIR RAIVHCLCPC LKNYDFGSST ETSDSHLTKA LSTFIHAEDF ARRRKRSVSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

rectum: 29 nTPM
colon: 19 nTPM
small intestine: 9.2 nTPM
urinary bladder: 6.8 nTPM
spleen: 5 nTPM
tonsil: 5 nTPM

Single-cell type

plasma cells: 25 nCPM
t-cells: 20 nCPM
nk-cells: 12 nCPM
foveolar cells: 2.9 nCPM
parietal cells: 1.8 nCPM
b-cells: 1.5 nCPM

Immune cell

T-reg: 12 nTPM
memory CD4 T-cell: 11 nTPM
memory CD8 T-cell: 5.1 nTPM
memory B-cell: 3.6 nTPM
total PBMC: 2.1 nTPM
gdT-cell: 1.3 nTPM

Brain region

white matter: 1.7 nTPM
medulla oblongata: 1.4 nTPM
pons: 1.1 nTPM
basal ganglia: 0.8 nTPM
cerebral cortex: 0.8 nTPM
midbrain: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.71
gnomAD pLI: 0
gnomAD missense Z: -0.04
DepMap mean gene effect: 0.17
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPR15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR15 as an antibody target. Whether an autoantibody or antibody against GPR15 could matter depends on whether native GPR15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR15 is annotated at the cell surface, where native GPR15 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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