GPR148
Probable G-protein coupled receptor 148
Also known as: GP148_HUMAN, PGR6
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8TDV2
- Gene
- GPR148
- Ensembl
- ENSG00000173302
- Chromosome
- 2
- Canonical length
- 347 aa
- Protein class
- G-protein coupled receptors, Predicted membrane proteins
- Subcellular location
- Plasma membrane
OverviewNCBI Gene
Predicted to enable odorant binding activity and olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of smell. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
347 residues, UniProt reviewed canonical sequence.
>Q8TDV2|GPR148
1 MGDELAPCPV GTTAWPALIQ LISKTPCMPQ AASNTSLGLG DLRVPSSMLY WLFLPSSLLA
61 AATLAVSPLL LVTILRNQRL RQEPHYLLPA NILLSDLAYI LLHMLISSSS LGGWELGRMA
121 CGILTDAVFA ACTSTILSFT AIVLHTYLAV IHPLRYLSFM SHGAAWKAVA LIWLVACCFP
181 TFLIWLSKWQ DAQLEEQGAS YILPPSMGTQ PGCGLLVIVT YTSILCVLFL CTALIANCFW
241 RIYAEAKTSG IWGQGYSRAR GTLLIHSVLI TLYVSTGVVF SLDMVLTRYH HIDSGTHTWL
301 LAANSEVLMM LPRAMLTYLY LLRYRQLLGM VRGHLPSRRH QAIFTISLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GPR148 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.37
- Highest tissue expression
- 0.5 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 0.5 nTPM
- pituitary gland: 0.4 nTPM
- stomach: 0.4 nTPM
- cerebral cortex: 0.1 nTPM
- hypothalamus: 0.1 nTPM
- pancreas: 0.1 nTPM
Single-cell type
- retinal amacrine cells: 0.8 nCPM
- goblet cells: 0.1 nCPM
- pancreatic islet cells: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 2.5 nTPM
- cerebral cortex: 2.3 nTPM
- pons: 1.6 nTPM
- hypothalamus: 1.3 nTPM
- medulla oblongata: 1.2 nTPM
- midbrain: 1.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.84
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.05
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- G protein-coupled receptor, rhodopsin-like
- GPCR, rhodopsin-like, 7TM
- 7 transmembrane receptor (rhodopsin family)
- G-protein Coupled Receptor 1 Superfamily Member
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GPR148 as an antibody target. Whether an autoantibody or antibody against GPR148 could matter depends on whether native GPR148 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GPR148 is annotated at the cell surface, where native GPR148 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label GPR148 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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