Seroatlas · Human Serome Atlas

GPR146

G-protein coupled receptor 146

Also known as: GP146_HUMAN, PGR8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96CH1
Gene: GPR146
Ensembl: ENSG00000164849
Chromosome: 7
Canonical length: 333 aa
Protein class: G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables G protein-coupled receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and regulation of cholesterol biosynthetic process. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

333 residues, UniProt reviewed canonical sequence.

>Q96CH1|GPR146
     1  MWSCSWFNGT GLVEELPACQ DLQLGLSLLS LLGLVVGVPV GLCYNALLVL ANLHSKASMT
    61  MPDVYFVNMA VAGLVLSALA PVHLLGPPSS RWALWSVGGE VHVALQIPFN VSSLVAMYST
   121  ALLSLDHYIE RALPRTYMAS VYNTRHVCGF VWGGALLTSF SSLLFYICSH VSTRALECAK
   181  MQNAEAADAT LVFIGYVVPA LATLYALVLL SRVRREDTPL DRDTGRLEPS AHRLLVATVC
   241  TQFGLWTPHY LILLGHTVII SRGKPVDAHY LGLLHFVKDF SKLLAFSSSF VTPLLYRYMN
   301  QSFPSKLQRL MKKLPCGDRH CSPDHMGVQQ VLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR146 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 43 nTPM
breast: 38 nTPM
lung: 23 nTPM
choroid plexus: 22 nTPM
liver: 21 nTPM
colon: 13 nTPM

Single-cell type

extravillous trophoblasts: 390 nCPM
syncytiotrophoblasts: 112 nCPM
lymphatic endothelial cells: 75 nCPM
breast lactating cells: 63 nCPM
vascular endothelial cells: 55 nCPM
migrating cytotrophoblasts: 51 nCPM

Immune cell

eosinophil: 95 nTPM
naive CD4 T-cell: 26 nTPM
T-reg: 15 nTPM
plasmacytoid DC: 14 nTPM
memory CD4 T-cell: 8.4 nTPM
naive CD8 T-cell: 4.9 nTPM

Brain region

choroid plexus: 34 nTPM
thalamus: 33 nTPM
pons: 26 nTPM
medulla oblongata: 26 nTPM
midbrain: 26 nTPM
cerebral cortex: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0.15
gnomAD missense Z: -0.42
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

G protein-coupled receptor activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
G-protein coupled estrogen receptor 1-like
7 transmembrane receptor (rhodopsin family)
G-protein coupled receptor 146

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR146 as an antibody target. Whether an autoantibody or antibody against GPR146 could matter depends on whether native GPR146 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR146 is annotated at the cell surface, where native GPR146 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR146 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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