Seroatlas · Human Serome Atlas

GPR142

Probable G-protein coupled receptor 142

Also known as: GP142_HUMAN, PGR2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z601
Gene: GPR142
Ensembl: ENSG00000257008
Chromosome: 17
Canonical length: 462 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins
Subcellular location: Plasma membrane,Cell Junctions,Cytosol

OverviewNCBI Gene

GPR142 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

462 residues, UniProt reviewed canonical sequence.

>Q7Z601|GPR142
     1  MSIMMLPMEQ KIQWVPTSLQ DITAVLGTEA YTEEDKSMVS HAQKSQHSCL SHSRWLRSPQ
    61  VTGGSWDLRI RPSKDSSSFR QAQCLRKDPG ANNHLESQGV RGTAGDADRE LRGPSEKATA
   121  GQPRVTLLPT PHVSGLSQEF ESHWPEIAER SPCVAGVIPV IYYSVLLGLG LPVSLLTAVA
   181  LARLATRTRR PSYYYLLALT ASDIIIQVVI VFAGFLLQGA VLARQVPQAV VRTANILEFA
   241  ANHASVWIAI LLTVDRYTAL CHPLHHRAAS SPGRTRRAIA AVLSAALLTG IPFYWWLDMW
   301  RDTDSPRTLD EVLKWAHCLT VYFIPCGVFL VTNSAIIHRL RRRGRSGLQP RVGKSTAILL
   361  GITTLFTLLW APRVFVMLYH MYVAPVHRDW RVHLALDVAN MVAMLHTAAN FGLYCFVSKT
   421  FRATVRQVIH DAYLPCTLAS QPEGMAAKPV MEPPGLPTGA EV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR142 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 1.7 nTPM

Expression across tissuesHPA

Tissue

stomach: 1.7 nTPM
pancreas: 0.7 nTPM
duodenum: 0.6 nTPM
spleen: 0.6 nTPM
lymph node: 0.5 nTPM
appendix: 0.4 nTPM

Single-cell type

foveolar cells: 1 nCPM
neuroendocrine cells: 0.8 nCPM
pancreatic islet cells: 0.8 nCPM
megakaryocyte-erythroid progenitors: 0.2 nCPM
astrocytes: 0.1 nCPM
bergmann glia: 0.1 nCPM

Immune cell

non-classical monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 2.7 nTPM
pons: 2.2 nTPM
medulla oblongata: 1.2 nTPM
white matter: 0.7 nTPM
cerebellum: 0.6 nTPM
midbrain: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0
gnomAD missense Z: 0.09
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

G protein-coupled receptor signaling pathway

Molecular functions

G protein-coupled receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR142 as an antibody target. Whether an autoantibody or antibody against GPR142 could matter depends on whether native GPR142 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR142 is annotated at the cell surface, where native GPR142 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR142 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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