Seroatlas · Human Serome Atlas

GPR141

Probable G-protein coupled receptor 141

Also known as: GP141_HUMAN, PGR13

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z602
Gene: GPR141
Ensembl: ENSG00000187037
Chromosome: 7
Canonical length: 305 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

GPR141 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

305 residues, UniProt reviewed canonical sequence.

>Q7Z602|GPR141
     1  MPGHNTSRNS SCDPIVTPHL ISLYFIVLIG GLVGVISILF LLVKMNTRSV TTMAVINLVV
    61  VHSVFLLTVP FRLTYLIKKT WMFGLPFCKF VSAMLHIHMY LTFLFYVVIL VTRYLIFFKC
   121  KDKVEFYRKL HAVAASAGMW TLVIVIVVPL VVSRYGIHEE YNEEHCFKFH KELAYTYVKI
   181  INYMIVIFVI AVAVILLVFQ VFIIMLMVQK LRHSLLSHQE FWAQLKNLFF IGVILVCFLP
   241  YQFFRIYYLN VVTHSNACNS KVAFYNEIFL SVTAISCYDL LLFVFGGSHW FKQKIIGLWN
   301  CVLCR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR141 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 25 nTPM
appendix: 3.7 nTPM
spleen: 2.9 nTPM
urinary bladder: 2.6 nTPM
placenta: 1.9 nTPM
gallbladder: 1.7 nTPM

Single-cell type

neutrophil progenitors: 11 nCPM
neutrophils: 10 nCPM
mast cells: 8.6 nCPM
monocyte progenitors: 4.2 nCPM
nk-cells: 4.1 nCPM
hematopoietic stem cells: 3.9 nCPM

Immune cell

classical monocyte: 11 nTPM
neutrophil: 11 nTPM
eosinophil: 8 nTPM
myeloid DC: 5.9 nTPM
gdT-cell: 4.4 nTPM
memory CD8 T-cell: 4.3 nTPM

Brain region

medulla oblongata: 14 nTPM
pons: 12 nTPM
white matter: 12 nTPM
thalamus: 11 nTPM
cerebellum: 11 nTPM
hypothalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.94
gnomAD pLI: 0
gnomAD missense Z: -0.48
DepMap mean gene effect: 0.21
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

inflammatory response

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR141 as an antibody target. Whether an autoantibody or antibody against GPR141 could matter depends on whether native GPR141 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR141 is annotated at the cell surface, where native GPR141 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR141 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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