GPR139
Probable G-protein coupled receptor 139
Also known as: GP139_HUMAN, PGR3
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6DWJ6
- Gene
- GPR139
- Ensembl
- ENSG00000180269
- Chromosome
- 16
- Canonical length
- 353 aa
- Protein class
- G-protein coupled receptors, Predicted membrane proteins, Transporters
OverviewNCBI Gene
This gene encodes a member of the rhodopsin family of G-protein-coupled receptors. The encoded protein is almost exclusively expressed in the central nervous system. L-tryptophan and L-phenylalanine may act as the physiologic ligands of the encoded protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Canonical amino-acid sequenceUniProt
353 residues, UniProt reviewed canonical sequence.
>Q6DWJ6|GPR139
1 MEHTHAHLAA NSSLSWWSPG SACGLGFVPV VYYSLLLCLG LPANILTVII LSQLVARRQK
61 SSYNYLLALA AADILVLFFI VFVDFLLEDF ILNMQMPQVP DKIIEVLEFS SIHTSIWITV
121 PLTIDRYIAV CHPLKYHTVS YPARTRKVIV SVYITCFLTS IPYYWWPNIW TEDYISTSVH
181 HVLIWIHCFT VYLVPCSIFF ILNSIIVYKL RRKSNFRLRG YSTGKTTAIL FTITSIFATL
241 WAPRIIMILY HLYGAPIQNR WLVHIMSDIA NMLALLNTAI NFFLYCFISK RFRTMAAATL
301 KAFFKCQKQP VQFYTNHNFS ITSSPWISPA NSHCIKMLVY QYDKNGKPIK VSPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GPR139 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 2.2 nTPM
Expression across tissuesHPA
Tissue
- basal ganglia: 2.2 nTPM
- hypothalamus: 0.8 nTPM
- bone marrow: 0.4 nTPM
- pituitary gland: 0.2 nTPM
- choroid plexus: 0.1 nTPM
- endometrium: 0.1 nTPM
Single-cell type
- lactotrophs: 67 nCPM
- thyrotrophs: 11 nCPM
- brain inhibitory neurons: 9.5 nCPM
- other brain neurons: 6.6 nCPM
- kupffer cells: 6.1 nCPM
- brain excitatory neurons: 3.3 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- hypothalamus: 10 nTPM
- medulla oblongata: 8.7 nTPM
- midbrain: 7.4 nTPM
- basal ganglia: 6.8 nTPM
- pons: 5.9 nTPM
- thalamus: 3.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.87
- gnomAD pLI
- 0.04
- gnomAD missense Z
- 0.91
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- G protein-coupled receptor signaling pathway
- phospholipase C-activating G protein-coupled receptor signaling pathway
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GPR139 as an antibody target. Whether an autoantibody or antibody against GPR139 could matter depends on whether native GPR139 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GPR139 is annotated at the cell surface, where native GPR139 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label GPR139 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...