Seroatlas · Human Serome Atlas

GPR137C

Integral membrane protein GPR137C

Also known as: DKFZp762F0713, G137C_HUMAN, TM7SF1L2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N3F9
Gene: GPR137C
Ensembl: ENSG00000180998
Chromosome: 14
Canonical length: 429 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to be involved in positive regulation of TORC1 signaling. Located in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

429 residues, UniProt reviewed canonical sequence.

>Q8N3F9|GPR137C
     1  MRVSVPGPAA AAAPAAGREP STPGGGSGGG GAVAAASGAA VPGSVQLALS VLHALLYAAL
    61  FAFAYLQLWR LLLYRERRLS YQSLCLFLCL LWAALRTTLF SAAFSLSGSL PLLRPPAHLH
   121  FFPHWLLYCF PSCLQFSTLC LLNLYLAEVI CKVRCATELD RHKILLHLGF IMASLLFLVV
   181  NLTCAMLVHG DVPENQLKWT VFVRALINDS LFILCAISLV CYICKITKMS SANVYLESKG
   241  MSLCQTVVVG SVVILLYSSR ACYNLVVVTI SQDTLESPFN YGWDNLSDKA HVEDISGEEY
   301  IVFGMVLFLW EHVPAWSVVL FFRAQRLNQN LAPAGMINSH SYSSRAYFFD NPRRYDSDDD
   361  LPRLGSSREG SLPNSQSLGW YGTMTGCGSS SYTVTPHLNG PMTDTAPLLF TCSNLDLNNH
   421  HSLYVTPQN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR137C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 26 nTPM
retina: 15 nTPM
cerebral cortex: 9.4 nTPM
hypothalamus: 8.3 nTPM
epididymis: 7.3 nTPM
spinal cord: 5.9 nTPM

Single-cell type

rod photoreceptor cells: 238 nCPM
retinal bipolar cells: 213 nCPM
adrenal medulla cells: 202 nCPM
brain excitatory neurons: 154 nCPM
brain inhibitory neurons: 148 nCPM
oligodendrocyte progenitor cells: 140 nCPM

Immune cell

NK-cell: 1.5 nTPM
MAIT T-cell: 1.4 nTPM
memory CD8 T-cell: 1.3 nTPM
gdT-cell: 0.9 nTPM
memory CD4 T-cell: 0.5 nTPM
naive CD8 T-cell: 0.5 nTPM

Brain region

cerebellum: 38 nTPM
thalamus: 29 nTPM
white matter: 24 nTPM
midbrain: 24 nTPM
medulla oblongata: 23 nTPM
cerebral cortex: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0.42
gnomAD missense Z: 0.81
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of TORC1 signaling

Cellular components

lysosomal membrane

Protein domainsUniProt · Pfam · InterPro

Integral membrane protein GPR137

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR137C as an antibody target. Whether an autoantibody or antibody against GPR137C could matter depends on whether native GPR137C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR137C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPR137C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...