Seroatlas · Human Serome Atlas

GPR137

Integral membrane protein GPR137

Also known as: C11orf4, G137A_HUMAN, GPR137A, TM7SF1L1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96N19
Gene: GPR137
Ensembl: ENSG00000173264
Chromosome: 11
Canonical length: 417 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nucleoli,Actin filaments

OverviewNCBI Gene

Predicted to be involved in several processes, including negative regulation of bone resorption; negative regulation of osteoclast differentiation; and positive regulation of TORC1 signaling. Located in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

417 residues, UniProt reviewed canonical sequence.

>Q96N19|GPR137
     1  MESNLSGLVP AAGLVPALPP AVTLGLTAAY TTLYALLFFS VYAQLWLVLL YGHKRLSYQT
    61  VFLALCLLWA ALRTTLFSFY FRDTPRANRL GPLPFWLLYC CPVCLQFFTL TLMNLYFAQV
   121  VFKAKVKRRP EMSRGLLAVR GAFVGASLLF LLVNVLCAVL SHRRRAQPWA LLLVRVLVSD
   181  SLFVICALSL AACLCLVARR APSTSIYLEA KGTSVCQAAA MGGAMVLLYA SRACYNLTAL
   241  ALAPQSRLDT FDYDWYNVSD QADLVNDLGN KGYLVFGLIL FVWELLPTTL LVGFFRVHRP
   301  PQDLSTSHIL NGQVFASRSY FFDRAGHCED EGCSWEHSRG ESTRCQDQAA TTTVSTPPHR
   361  RDPPPSPTEY PGPSPPHPRP LCQVCLPLLA QDPGGRGYPL LWPAPCCSCH SELVPSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR137 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 189 nTPM

Expression across tissuesHPA

Tissue

testis: 189 nTPM
cerebral cortex: 57 nTPM
basal ganglia: 53 nTPM
hippocampal formation: 49 nTPM
amygdala: 48 nTPM
cerebellum: 43 nTPM

Single-cell type

late spermatids: 1,055 nCPM
late primary spermatocytes: 316 nCPM
early spermatids: 176 nCPM
syncytiotrophoblasts: 156 nCPM
extravillous trophoblasts: 104 nCPM
early primary spermatocytes: 95 nCPM

Immune cell

neutrophil: 6.9 nTPM
eosinophil: 4.6 nTPM
naive B-cell: 3.9 nTPM
plasmacytoid DC: 3.1 nTPM
myeloid DC: 3 nTPM
MAIT T-cell: 2.9 nTPM

Brain region

cerebral cortex: 94 nTPM
pons: 84 nTPM
thalamus: 84 nTPM
amygdala: 80 nTPM
medulla oblongata: 79 nTPM
hippocampal formation: 77 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0.67
gnomAD missense Z: 1.04
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

lysosomal membrane

Protein domainsUniProt · Pfam · InterPro

Integral membrane protein GPR137

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR137 as an antibody target. Whether an autoantibody or antibody against GPR137 could matter depends on whether native GPR137 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR137 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPR137 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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