Seroatlas · Human Serome Atlas

GPR132

Probable G-protein coupled receptor 132

Also known as: G2A, GP132_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UNW8
Gene: GPR132
Ensembl: ENSG00000183484
Chromosome: 14
Canonical length: 380 aa
Protein class: G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein was reported to be a receptor for lysophosphatidylcholine action, but PubMedID: 15653487 retracts this finding and instead suggests this protein to be an effector of lysophosphatidylcholine action. This protein may have proton-sensing activity and may be a receptor for oxidized free fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

380 residues, UniProt reviewed canonical sequence.

>Q9UNW8|GPR132
     1  MCPMLLKNGY NGNATPVTTT APWASLGLSA KTCNNVSFEE SRIVLVVVYS AVCTLGVPAN
    61  CLTAWLALLQ VLQGNVLAVY LLCLALCELL YTGTLPLWVI YIRNQHRWTL GLLACKVTAY
   121  IFFCNIYVSI LFLCCISCDR FVAVVYALES RGRRRRRTAI LISACIFILV GIVHYPVFQT
   181  EDKETCFDML QMDSRIAGYY YARFTVGFAI PLSIIAFTNH RIFRSIKQSM GLSAAQKAKV
   241  KHSAIAVVVI FLVCFAPYHL VLLVKAAAFS YYRGDRNAMC GLEERLYTAS VVFLCLSTVN
   301  GVADPIIYVL ATDHSRQEVS RIHKGWKEWS MKTDVTRLTH SRDTEELQSP VALADHYTFS
   361  RPVHPPGSPC PAKRLIEESC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR132 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 7.5 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 7.5 nTPM
lymph node: 7.2 nTPM
spleen: 7.2 nTPM
appendix: 6.6 nTPM
thyroid gland: 4.3 nTPM
tonsil: 4.2 nTPM

Single-cell type

neutrophils: 346 nCPM
monocytes: 253 nCPM
cdc: 186 nCPM
macrophages: 118 nCPM
t-cells: 110 nCPM
endometrial secretory cells: 86 nCPM

Immune cell

basophil: 9.5 nTPM
non-classical monocyte: 9.1 nTPM
intermediate monocyte: 7.6 nTPM
classical monocyte: 6 nTPM
gdT-cell: 6 nTPM
MAIT T-cell: 5.8 nTPM

Brain region

medulla oblongata: 4 nTPM
thalamus: 3.4 nTPM
white matter: 3.4 nTPM
choroid plexus: 3.1 nTPM
midbrain: 3 nTPM
pons: 3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.56
gnomAD pLI: 0.02
gnomAD missense Z: 1.4
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

G protein-coupled receptor activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
7 transmembrane receptor (rhodopsin family)
G2A lysophosphatidylcholine receptor

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR132 as an antibody target. Whether an autoantibody or antibody against GPR132 could matter depends on whether native GPR132 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR132 is annotated at the cell surface, where native GPR132 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR132 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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