Seroatlas · Human Serome Atlas

GPR108

Protein GPR108

Also known as: GP108_HUMAN, LUSTR2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NPR9
Gene
GPR108
Ensembl
ENSG00000125734
Chromosome
19
Canonical length
543 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Golgi apparatus,Vesicles

OverviewNCBI Gene

Predicted to be involved in negative regulation of toll-like receptor signaling pathway. Predicted to act upstream of or within defense response to virus; protein catabolic process; and type I interferon-mediated signaling pathway. Located in trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

543 residues, UniProt reviewed canonical sequence.

>Q9NPR9|GPR108
     1  MAVSERRGLG RGSPAEWGQR LLLVLLLGGC SGRIHQLALT GEKRADIQLN SFGFYTNGSL
    61  EVELSVLRLG LREAEEKSLL VGFSLSRVRS GRVRSYSTRD FQDCPLQKNS SSFLVLFLIN
   121  TKDLQVQVRK YGEQKTLFIF PGLLPEAPSK PGLPKPQATV PRKVDGGGTS AASKPKSTPA
   181  VIQGPSGKDK DLVLGLSHLN NSYNFSFHVV IGSQAEEGQY SLNFHNCNNS VPGKEHPFDI
   241  TVMIREKNPD GFLSAAEMPL FKLYMVMSAC FLAAGIFWVS ILCRNTYSVF KIHWLMAALA
   301  FTKSISLLFH SINYYFINSQ GHPIEGLAVM YYIAHLLKGA LLFITIALIG SGWAFIKYVL
   361  SDKEKKVFGI VIPMQVLANV AYIIIESREE GASDYVLWKE ILFLVDLICC GAILFPVVWS
   421  IRHLQDASGT DGKVAVNLAK LKLFRHYYVM VICYVYFTRI IAILLQVAVP FQWQWLYQLL
   481  VEGSTLAFFV LTGYKFQPTG NNPYLQLPQE DEEDVQMEQV MTDSGFREGL SKVNKTASGR
   541  ELL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR108 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
56 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 56 nTPM
  • parathyroid gland: 47 nTPM
  • pancreas: 45 nTPM
  • adrenal gland: 43 nTPM
  • kidney: 41 nTPM
  • thyroid gland: 39 nTPM

Single-cell type

  • late spermatids: 102 nCPM
  • esophageal apical cells: 42 nCPM
  • platelets: 41 nCPM
  • late primary spermatocytes: 40 nCPM
  • neutrophils: 37 nCPM
  • breast lactating cells: 36 nCPM

Immune cell

  • neutrophil: 190 nTPM
  • total PBMC: 141 nTPM
  • non-classical monocyte: 137 nTPM
  • eosinophil: 130 nTPM
  • classical monocyte: 123 nTPM
  • intermediate monocyte: 114 nTPM

Brain region

  • choroid plexus: 31 nTPM
  • cerebellum: 30 nTPM
  • hypothalamus: 30 nTPM
  • basal ganglia: 29 nTPM
  • thalamus: 29 nTPM
  • medulla oblongata: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.06
gnomAD pLI
0
gnomAD missense Z
0.53
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR108 as an antibody target. Whether an autoantibody or antibody against GPR108 could matter depends on whether native GPR108 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR108 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPR108 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GPR108. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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