Seroatlas · Human Serome Atlas

GPR101

Probable G-protein coupled receptor 101

Also known as: GP101_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96P66
Gene: GPR101
Ensembl: ENSG00000165370
Chromosome: X
Canonical length: 508 aa
Protein class: Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is an orphan G protein-coupled receptor of unknown function. The encoded protein is a member of a family of proteins that contain seven transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

508 residues, UniProt reviewed canonical sequence.

>Q96P66|GPR101
     1  MTSTCTNSTR ESNSSHTCMP LSKMPISLAH GIIRSTVLVI FLAASFVGNI VLALVLQRKP
    61  QLLQVTNRFI FNLLVTDLLQ ISLVAPWVVA TSVPLFWPLN SHFCTALVSL THLFAFASVN
   121  TIVVVSVDRY LSIIHPLSYP SKMTQRRGYL LLYGTWIVAI LQSTPPLYGW GQAAFDERNA
   181  LCSMIWGASP SYTILSVVSF IVIPLIVMIA CYSVVFCAAR RQHALLYNVK RHSLEVRVKD
   241  CVENEDEEGA EKKEEFQDES EFRRQHEGEV KAKEGRMEAK DGSLKAKEGS TGTSESSVEA
   301  RGSEEVRESS TVASDGSMEG KEGSTKVEEN SMKADKGRTE VNQCSIDLGE DDMEFGEDDI
   361  NFSEDDVEAV NIPESLPPSR RNSNSNPPLP RCYQCKAAKV IFIIIFSYVL SLGPYCFLAV
   421  LAVWVDVETQ VPQWVITIII WLFFLQCCIH PYVYGYMHKT IKKEIQDMLK KFFCKEKPPK
   481  EDSHPDLPGT EGGTEGKIVP SYDSATFP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR101 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 12 nTPM
hypothalamus: 4.7 nTPM
cerebellum: 0.2 nTPM
midbrain: 0.2 nTPM
amygdala: 0.1 nTPM
hippocampal formation: 0.1 nTPM

Single-cell type

other brain neurons: 15 nCPM
brain inhibitory neurons: 8 nCPM
ocular epithelial cells: 1.5 nCPM
epididymal basal cells: 0.9 nCPM
brain excitatory neurons: 0.8 nCPM
innate lymphoid cells: 0.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 31 nTPM
basal ganglia: 26 nTPM
thalamus: 4.8 nTPM
pons: 3.5 nTPM
medulla oblongata: 3.1 nTPM
spinal cord: 2.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GPR101.

Disease | AllUniProt

Conditions GPR101 is implicated in, by any mechanism.

Pituitary adenoma 2, growth hormone-secreting (PITA2) MIM:300943

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 90 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Pituitary adenoma, growth hormone-secreting, 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.57
gnomAD pLI: 0.7
gnomAD missense Z: 0.64
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

G protein-coupled receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR101 as an antibody target. Whether an autoantibody or antibody against GPR101 could matter depends on whether native GPR101 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR101 is annotated at the cell surface, where native GPR101 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR101 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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