Seroatlas · Human Serome Atlas

GPM6B

Neuronal membrane glycoprotein M6-b

Also known as: GPM6B_HUMAN, M6B, MGC17150, MGC54284

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13491
Gene
GPM6B
Ensembl
ENSG00000046653
Chromosome
X
Canonical length
265 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a membrane glycoprotein that belongs to the proteolipid protein family. Proteolipid protein family members are expressed in most brain regions and are thought to be involved in cellular housekeeping functions such as membrane trafficking and cell-to-cell communication. This protein may also be involved in osteoblast differentiation. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes Y and 22. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

265 residues, UniProt reviewed canonical sequence.

>Q13491|GPM6B
     1  MKPAMETAAE ENTEQSQERK GCFECCIKCL GGVPYASLVA TILCFSGVAL FCGCGHVALA
    61  GTVAILEQHF STNASDHALL SEVIQLMQYV IYGIASFFFL YGIILLAEGF YTTSAVKELH
   121  GEFKTTACGR CISGMFVFLT YVLGVAWLGV FGFSAVPVFM FYNIWSTCEV IKSPQTNGTT
   181  GVEQICVDIR QYGIIPWNAF PGKICGSALE NICNTNEFYM SYHLFIVACA GAGATVIALL
   241  IYMMATTYNY AVLKFKSRED CCTKF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPM6B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
710 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 710 nTPM
  • cerebral cortex: 437 nTPM
  • amygdala: 430 nTPM
  • hippocampal formation: 389 nTPM
  • midbrain: 365 nTPM
  • basal ganglia: 349 nTPM

Single-cell type

  • müller glia: 1,896 nCPM
  • oligodendrocytes: 1,811 nCPM
  • bergmann glia: 1,588 nCPM
  • schwann cells: 1,459 nCPM
  • astrocytes: 1,043 nCPM
  • melanocytes: 877 nCPM

Immune cell

  • plasmacytoid DC: 78 nTPM
  • total PBMC: 0.7 nTPM
  • myeloid DC: 0.3 nTPM
  • basophil: 0.2 nTPM
  • gdT-cell: 0.2 nTPM
  • MAIT T-cell: 0.2 nTPM

Brain region

  • white matter: 1,203 nTPM
  • medulla oblongata: 927 nTPM
  • cerebellum: 814 nTPM
  • spinal cord: 798 nTPM
  • basal ganglia: 746 nTPM
  • hypothalamus: 663 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GPM6B.

Disease | ImmuneIEDB

Conditions an epitope on GPM6B was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.59
gnomAD pLI
0.35
gnomAD missense Z
1.99
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPM6B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

  • SERT

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPM6B as an antibody target. Whether an autoantibody or antibody against GPM6B could matter depends on whether native GPM6B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPM6B is annotated at the cell surface, where native GPM6B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPM6B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GPM6B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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