Seroatlas · Human Serome Atlas

GPHB5

Glycoprotein hormone beta-5

Also known as: GPB5, GPHB5_HUMAN, ZLUT1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86YW7
Gene
GPHB5
Ensembl
ENSG00000179600
Chromosome
14
Canonical length
130 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

GPHB5 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

130 residues, UniProt reviewed canonical sequence.

>Q86YW7|GPHB5
     1  MKLAFLFLGP MALLLLAGYG CVLGASSGNL RTFVGCAVRE FTFLAKKPGC RGLRITTDAC
    61  WGRCETWEKP ILEPPYIEAH HRVCTYNETK QVTVKLPNCA PGVDPFYTYP VAIRCDCGAC
   121  STATTECETI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPHB5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
0.1 nTPM

Expression across tissuesHPA

Tissue

  • retina: 0.1 nTPM
  • testis: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • respiratory ionocytes: 2.5 nCPM
  • gastric progenitor cells: 1.3 nCPM
  • foveolar cells: 1 nCPM
  • early spermatids: 0.8 nCPM
  • thymocytes: 0.8 nCPM
  • brain excitatory neurons: 0.5 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.9 nTPM
  • pons: 0.5 nTPM
  • white matter: 0.5 nTPM
  • amygdala: 0.4 nTPM
  • basal ganglia: 0.4 nTPM
  • cerebellum: 0.4 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPHB5 as an antibody target. Whether an autoantibody or antibody against GPHB5 could matter depends on whether native GPHB5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPHB5 is annotated as secreted, so native GPHB5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label GPHB5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GPHB5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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