Seroatlas · Human Serome Atlas

GPC6

Glypican-6

Also known as: GPC6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y625
Gene
GPC6
Ensembl
ENSG00000183098
Chromosome
13
Canonical length
555 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Golgi apparatus,Vesicles
Secretome location
Intracellular and membrane

OverviewNCBI Gene

The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Mutations in this gene are associated with omodysplasia 1. [provided by RefSeq, Nov 2016]

Canonical amino-acid sequenceUniProt

555 residues, UniProt reviewed canonical sequence.

>Q9Y625|GPC6
     1  MPSWIGAVIL PLLGLLLSLP AGADVKARSC GEVRQAYGAK GFSLADIPYQ EIAGEHLRIC
    61  PQEYTCCTTE MEDKLSQQSK LEFENLVEET SHFVRTTFVS RHKKFDEFFR ELLENAEKSL
   121  NDMFVRTYGM LYMQNSEVFQ DLFTELKRYY TGGNVNLEEM LNDFWARLLE RMFQLINPQY
   181  HFSEDYLECV SKYTDQLKPF GDVPRKLKIQ VTRAFIAART FVQGLTVGRE VANRVSKVSP
   241  TPGCIRALMK MLYCPYCRGL PTVRPCNNYC LNVMKGCLAN QADLDTEWNL FIDAMLLVAE
   301  RLEGPFNIES VMDPIDVKIS EAIMNMQENS MQVSAKVFQG CGQPKPAPAL RSARSAPENF
   361  NTRFRPYNPE ERPTTAAGTS LDRLVTDIKE KLKLSKKVWS ALPYTICKDE SVTAGTSNEE
   421  ECWNGHSKAR YLPEIMNDGL TNQINNPEVD VDITRPDTFI RQQIMALRVM TNKLKNAYNG
   481  NDVNFQDTSD ESSGSGSGSG CMDDVCPTEF EFVTTEAPAV DPDRREVDSS AAQRGHSLLS
   541  WSLTCIVLAL QRLCR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPC6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 18 nTPM
  • liver: 17 nTPM
  • gallbladder: 16 nTPM
  • seminal vesicle: 14 nTPM
  • blood vessel: 11 nTPM
  • urinary bladder: 11 nTPM

Single-cell type

  • pituicytes/fscs: 3,669 nCPM
  • podocytes: 2,171 nCPM
  • rod photoreceptor cells: 1,571 nCPM
  • bergmann glia: 1,540 nCPM
  • corticotrophs: 1,145 nCPM
  • adipocytes: 1,074 nCPM

Immune cell

  • NK-cell: 0.4 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • hypothalamus: 8.6 nTPM
  • midbrain: 7.1 nTPM
  • pons: 6.8 nTPM
  • white matter: 6.4 nTPM
  • spinal cord: 6.2 nTPM
  • thalamus: 6.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GPC6.

Disease | AllUniProt

Conditions GPC6 is implicated in, by any mechanism.

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 380 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Autosomal recessive omodysplasia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.14
gnomAD missense Z
0.9
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPC6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPC6 as an antibody target. Whether an autoantibody or antibody against GPC6 could matter depends on whether native GPC6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPC6 is annotated at the cell surface, where native GPC6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPC6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GPC6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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