Seroatlas · Human Serome Atlas

GPC5

Glypican-5

Also known as: GPC5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P78333
Gene
GPC5
Ensembl
ENSG00000179399
Chromosome
13
Canonical length
572 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

572 residues, UniProt reviewed canonical sequence.

>P78333|GPC5
     1  MDAQTWPVGF RCLLLLALVG SARSEGVQTC EEVRKLFQWR LLGAVRGLPD SPRAGPDLQV
    61  CISKKPTCCT RKMEERYQIA ARQDMQQFLQ TSSSTLKFLI SRNAAAFQET LETLIKQAEN
   121  YTSILFCSTY RNMALEAAAS VQEFFTDVGL YLFGADVNPE EFVNRFFDSL FPLVYNHLIN
   181  PGVTDSSLEY SECIRMARRD VSPFGNIPQR VMGQMGRSLL PSRTFLQALN LGIEVINTTD
   241  YLHFSKECSR ALLKMQYCPH CQGLALTKPC MGYCLNVMRG CLAHMAELNP HWHAYIRSLE
   301  ELSDAMHGTY DIGHVLLNFH LLVNDAVLQA HLNGQKLLEQ VNRICGRPVR TPTQSPRCSF
   361  DQSKEKHGMK TTTRNSEETL ANRRKEFINS LRLYRSFYGG LADQLCANEL AAADGLPCWN
   421  GEDIVKSYTQ RVVGNGIKAQ SGNPEVKVKG IDPVINQIID KLKHVVQLLQ GRSPKPDKWE
   481  LLQLGSGGGM VEQVSGDCDD EDGCGGSGSG EVKRTLKITD WMPDDMNFSD VKQIHQTDTG
   541  STLDTTGAGC AVATESMTFT LISVVMLLPG IW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 13 nTPM
  • amygdala: 9.4 nTPM
  • cerebral cortex: 9 nTPM
  • kidney: 6.8 nTPM
  • midbrain: 6.4 nTPM
  • testis: 5.7 nTPM

Single-cell type

  • astrocytes: 5,171 nCPM
  • sertoli cells: 3,977 nCPM
  • gonadotrophs: 3,182 nCPM
  • distal convoluted tubule cells: 2,589 nCPM
  • corticotrophs: 1,891 nCPM
  • alveolar cells type 1: 1,706 nCPM

Immune cell

  • NK-cell: 0.4 nTPM
  • non-classical monocyte: 0.3 nTPM
  • memory CD8 T-cell: 0.2 nTPM
  • gdT-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • hypothalamus: 61 nTPM
  • pons: 56 nTPM
  • basal ganglia: 51 nTPM
  • midbrain: 41 nTPM
  • thalamus: 41 nTPM
  • medulla oblongata: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
-0.59
DepMap mean gene effect
0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPC5 as an antibody target. Whether an autoantibody or antibody against GPC5 could matter depends on whether native GPC5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPC5 is annotated at the cell surface, where native GPC5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPC5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GPC5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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